OBJECTIVES We investigated the incidence of Epstein-Barr virus (EBV) infection in surgical specimens of squamous cell carcinoma of the larynx and vocal cord nodules. PATIENTS AND METHODS Formalin-fixed, paraffin-embedded tissue samples randomly selected from 22 patients with squamous cell carcinoma of the larynx (20 males, 2 females; mean age 52 years) and from 17 patients with vocal cord nod...

Background: Pancreatic carcinoma is the fourth-leading cause of cancer death in the United States and due to its late presentation, only few patients would be candidates for the curative treatment of pancreactomy. Monoclonal antibodies have brought hope to targeted therapy.Objectives: To identify new biomarkers, a panel of monoclonal antibodies was genera...

Abstract Background One of the most problematic issues laryngeal carcinoma is recurrence after surgery one causes this study tries to find its relevance peri neural invasion. Aim work To determine whether there a relationship between perineural invasion and cervical nodal metastases squamous cell carcinoma. Methods Between December 2019 September 2020, was conducted on 30 individuals who had SC...

background: our preliminary data on the protein expression of sort1 in ovarian carcinoma tissues showed that sortilin was overexpressed in ovarian carcinoma patients and cell lines, while non-malignant ovaries expressed comparably lower amount of this protein. in spite of diverse ligands and also different putative functions of sortilin (ntr3), the function of overexpressed sortilin in ovarian ...

DNA topoisomerase II-α (Topo II-α) is essential for numerous cell processes, including DNA replication, transcription, recombination, and chromosome separation and condensation. Altered Topo II-α expression may lead to carcinogenesis and cancer progression. The aim of the present study was to investigate the association between Topo II-α expression levels and clinicopathological data from laryn...

Androgen receptors (ARs) which are implicated in the pathogenesis of several malignancies can also be a possible downstream effector in laryngeal cancer. In the present study, 97 invasive squamous laryngeal carcinomas were studied by immunohistochemistry for protein expression of AR. Androgen receptors were expressed in 52.6% of tumor specimens, suggesting their implication in the pathogenesis ...

Background:The incidence rate of head and neck cancer in the world is about 560,000 new cases a year. Larynx cancer is the most common malignancy in head and neck in Iran. The most common head and neck carcinoma is the malignancy of squamous epithelial cells. This study was conducted to determine the survival rate of patients undergoing nonsurgical treatment methods for larynge...

OBJECTIVES/HYPOTHESIS To determine the incidence of level IIB lymph node metastasis in patients with laryngeal or hypopharyngeal squamous cell carcinoma and to evaluate the need for elective and therapeutic neck dissection of level IIB. STUDY DESIGN Retrospective cohort study and review of the literature. METHODS Patients with laryngeal or hypopharyngeal squamous cell carcinoma (N = 65) wer...

Laryngeal squamous cell carcinoma is the most common form of head and neck squamous cell carcinoma. Multiple approaches have been applied to treat this type of cancer; however, no significant improvement in survival rate has been achieved. In the present study, the role of nemo‑like kinase (NLK) in human laryngeal carcinoma Hep‑2 cells was investigated. NLK has been identified as an important re...