Significance Predatory hunting involves measured risk taking by the predator to anticipate dangerous defensive behavior from prey. This a mechanism where motivation hunt can overcome behaviors toward prey unlock attack. Here, we found that activation of subset GABAergic neurons in lateral hypothalamus (LHA) promotes but not feeding behavior. Stimulation projections these periaqueductal gray (PA...

The hypothalamus has been recognized for a long time as a pivotal structure in the regulation of appetite. It moved even more center stage when the adipocytederived hormone leptin was found to exert effects on the ventrobasal area of the hypothalamus, notably the arcuate nucleus. Based on anatomical experiments, this region of the brain has been suspected for a long time of mediating satiety, s...

The central representation of neurogenically mediated coronary vasoconstriction produced by activation of the sympathetic nervous system was examined in anesthetized cats instrumented for continuous recording of coronary and femoral blood flows, arterial pressure, and heart rate. Electrical stimulation in a small region of perifornical lateral hypothalamus increased arterial pressure, heart rat...

Stress is a reaction to unwanted events disturbing body homeostasis which influences its pathways and target areas. Stress affects the brain through the lateral hypothalamic area (LHA) orexinergic system that mediates the effect of corticotropin-releasing hormone (CRH) through CRH receptor type 1 (CRHr1). Therefore, this study explores the outcome of stress exposure on anxiety development and t...

This study examined the role of dopamine D1-like receptor transmission in the lateral hypothalamus (LH) in flavor preference learning induced by intragastric (IG) infusions of glucose. Rats fitted with gastric catheters were injected daily in the LH with either saline or SCH23390 (12 nmol/brain), 10 min prior to training sessions with a flavor (CS+) paired with IG infusions of 8% glucose and a ...

The largest synaptic input to the sleep-promoting ventrolateral preoptic area (VLPO) [1] arises from the lateral hypothalamus [2], a brain area associated with arousal [3-5]. However, the neurochemical identity of the majority of these VLPO-projecting neurons within the lateral hypothalamus (LH), as well as their function in the arousal network, remains unknown. Herein we describe a population ...

The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combinati...

Feeding satisfies metabolic need but is also controlled by external stimuli, like palatability or predator threat. Nucleus accumbens shell (NAcSh) projections to the lateral hypothalamus (LH) are implicated in mediating such feeding control, but the neurons involved and their mechanism of action remain elusive. We show that dopamine D1R-expressing NAcSh neurons (D1R-MSNs) provide the dominant s...

the boundary of a system. The characteristics of the threshold bared of insulation. The effects of stimulation were tested gradients suggest that, with intensities on the order of 25 pa, the for 5 days with the electrode at each lateral hypothalamic effective spread of current from small monopolar electrodes may site; each week the electrodes were moved approximately be as little as l/8 mm. The...

CONTROL OF FOOD INTAKE is complex, involving multiple interconnected pathways and signal elements. A paper by Wang and Kotz (11) in this issue of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology illustrates some of the complexity and carries implications for how the regulation of food intake is integrated into the daily life of humans and other animals. Wang...