The tissue concentration of an endogenous beta-galactoside-specific lectin is developmentally regulated in rabbit tissues during foetal and neonatal development. Immunoassay data and localization studies both indicate that the lectin is particularly associated with late embryonic and early postnatal development. No lectin could be detected in embryos prior to 21 days of gestation, whereas many ...

Changes in lectin activity during development of embryonic chick skin were studied. In the dorsal skin of the chick embryo in which feathers were formed, lectin activity first increased, during the period of dermal condensation, and then it decreased during the development of feathers. A similar change in lectin activity was also found in the anterior shank skin, the prospective scale region of...

conclusions vaccine based on the conjugation of p. aeruginosa pao-1 lps with dt increased anti-lps antibodies and had a significant potential to protect against pseudomonas infections. background treatment of pseudomonas aeruginosa pao-1 infections through immunological means has been proved to be efficient and protective. objectives the purpose of this study was to produce a conjugate vaccine ...

miRNAs as one of the potential therapeutic agents have been recently considered for cancer treatment. AS1411 (aptNCL) is a DNA aptamer specifically binding to nucleolin protein on the cancer cell surface with antiproliferative effect. The aim of the study was to develop a conjugate consisted of aptNCL (as targeted delivery of therapeutic agent) and miRNA let-7d (as a tumor suppressor) using two...

it is well known that glycoconjugate components of the cell surface and extracellular matrix, play an essential role(s) in many developmental phenomena such as cell differentiation, migration, and cellular interactions. the purpose of this study was to investigate distribution of this macromolecules during differentiation of the notochord and paraxial mesoderm. formalin fixed paraffin sections ...

objective(s):the aim of this study was to evaluate distribution and changes of glycoconjugates of retinal photoreceptors during both pre- and postnatal development. materials and methods: tissue sections from days 15 to 20 of wistar rat embryos and 1 to 12 postnatal days of rat newborns including developing eye were prepared for lectinhistochemistry technique. horseradish peroxidase (hrp)-label...

In this study, we fabricated PCL-nanoparticles by encapsulating dual drugs as amphotericin B and doxorubicin via double-emulsion solvent evaporation method also incorporated with ligand-lectin for targeting the infested macrophage cells and prove importance against VL. Different independent processing parameters were assessed systematically to enhance the incorporation of the dual agents with d...

BACKGROUND Lectins are carbohydrate binding proteins or glycoproteins that bind reversibly to specific carbohydrates present on the apposing cells, which are responsible for their ability to agglutinate red blood cells, lymphocytes, fibroblasts, etc. Interest in lectins has been intensified due to their carbohydrate specificity as they can be valuable reagents for the investigation of cell surf...

A soluble lactose-binding lectin with subunit Mr of 14,500 is believed to function by interacting with extracellular glycoconjugates, because it has been detected extracellularly by immunohistochemistry. This localization has been questioned, however, since the lectin lacks a secretion signal sequence, which challenges the contention that it is secreted. We have demonstrated externalization of ...

mannan-binding lectin (mbl) is a vital protein of innate immune system and has two critical functions: complement activation through the lectin pathway and opsonization. mbl deficiency has been classified as the most common inherited immunodeficiency known in humans (about 30% of the population), and is associated with predisposition to infections and high risk of some autoimmune diseases. the ...