Esophageal cancers have extensive local growth and early lymph node involvement before widespread dissemination. Interconnexions between lymphatic channels of the esophagus provide a submucous passway for the lymphatic dissemination of cancer. Viable tumor emboli can be found sometimes as much as 8 cm distant from the primary cancer. The disease causes death by both local growth and distant met...

Background: Despite the relative success of surgical resection followed by proton, proton/photon, or conventional radiotherapy in terms of recurrence-free survival, chordomas are still associated with a high rate of recurrence. To our knowledge there are only very few reported cases of this rare tumor detected by F-18 FDG-PET. Materials and Methods: In this case we show the significanc...

Background: Endometrial cancer is the second most common type of gynecologic malignancy. Studies on factors lymphatic metastases are few. This study aimed to determine clinical and pathological characteristics that can predict lymph node metastases.
 Purpose: To correlation clinicopathological with LNM (Lymph Node Metastases) in Cancer (EC).
 Methods: used observational analysis a cro...

The lymphatic vasculature collects and drains fluid and cells from the periphery through lymph nodes (LNs) for immune monitoring, and then returns lymph to the bloodstream. During immune responses LNs enlarge and remodel, featuring extensive growth of lymphatic sinuses (lymphangiogenesis). This LN lymphangiogenesis also arises in cancer, and is associated with altered lymph drainage through LNs...

Metastases from colorectal cancer can occur either through the lymphatic or by hematogenous spread. The most common metastatic sites are lung and liver. Nasopharyngeal metastasis has never been previously reported in literature on internet databases we found. In this paper, present case of a 79-year-old male suffering adenocarcinoma rectum with distant metastases to liver, lung, nasopharynx. Ov...

OBJECTIVE To prospectively assess pelvic and para-aortic lymph node metastases in endometrial cancer with lymphatic dissemination, emphasizing the examination of para-aortic metastases relative to the inferior mesenteric artery (IMA). METHODS Over 36 months, 422 consecutive patients were managed by predefined surgical guidelines differentiating low-risk patients from patients at risk for diss...

Lymphatic vessels play a major role in cancer progression and in postsurgical lymphedema, and several new therapeutic approaches targeting lymphatics are currently being developed. Thus, there is a critical need for quantitative imaging methods to measure lymphatic flow. Indocyanine green (ICG) has been used for optical imaging of the lymphatic system, but it is unstable in solution and may rap...

Lymphatic anatomy has become increasingly clinically important as surgical techniques evolve for investigating and treating cancer metastases. However, due to limited anatomical techniques available, research in this field has been insufficient. The techniques of computed tomography (CT) and magnetic resonance (MR) lymphangiography have not been described previously in the imaging of cadaveric ...

BACKGROUND To evaluate whether tumour-associated lymphangiogenesis, that is the formation of new lymphatic vessels (LVs) induced by a tumour, occurs in and around conjunctival malignant melanoma (MM). METHODS Clinical files and conjunctival specimens of 20 patients with histologically diagnosed conjunctival MM were analysed. Sections were stained with LYVE-1 and podoplanin antibodies as speci...

Breast involution following pregnancy has been implicated in the high rates of metastasis observed in postpartum breast cancers; however, it is not clear how this remodeling process promotes metastasis. Here, we demonstrate that human postpartum breast cancers have increased peritumor lymphatic vessel density that correlates with increased frequency of lymph node metastases. Moreover, lymphatic...