the objective of the present study was to investigate the role of nanocarrier of magnetic isotope of 25-mg2+ (pmc16) in liver toxicity, atp content and oxidative stress due to malathion (mal) exposure. pmc16 nanoparticle were administered in different doses (0.05, 0.1 and 0.2 ld50) intravenously (iv) 40 minutes after a single mal (0.25 ld50= 207 mg/kg) intraperitoneal (ip) injection as a comple...

The presence of maltose induces M4L gene expression in Saccharomyces cells, but little is known abouthow maltose is sensed. Strains with all maltose permease genes deleted are unable to induce MAL geneexpression. In this study, we examined the role of maltose permease in maltose sensing by substituting a heterologous transporter for the native maltose permease. PmSUC2 encodes a sucrose transpor...

In Saccharomyces cerevisiae, the gene functions required to ferment the disaccharide maltose are encoded by the MAL loci. Any one of five highly sequence homologous MAL loci identified in various S. cerevisiae strains (called MAL1, 2, 3, 4 and 6) is sufficient to ferment maltose. Each is a complex of three genes encoding maltose permease, maltase and a transcription activator. This family of lo...

Five members of a new family of polyoxometalate (POM)-ligated trinuclear lanthanoid (Ln) clusters with the general formula K20Li2[Ln3(μ3-OH)(H2O)8(AsW9O33)(AsW10O35(mal))]2·17H2O [Ln = Dy (1Dy), Tb (2Tb), Gd (3Gd), Eu (4Eu), and Sm (5Sm), mal = malate] have been synthesized, all of which consist of the dimeric {[Ln3(μ3-OH)(H2O)8(AsW9O33)[AsW10O35(mal)]}(11-) polyanion constructed from a {AsW9O3...

Expression of the src-family kinase lymphocyte-specific protein tyrosine kinase (Lck) at the plasma membrane is essential for it to fulfill its pivotal role in signal transduction in T lymphocytes. MAL, an integral membrane protein expressed in specific types of lymphoma, has been shown to play an important role in targeting Lck to the plasma membrane. Here we report that MAL interacts with Inv...

The acute and long-term effects of the local perfusion of 3,4-methylenedioxymethamphetamine (MDMA) and the interaction with the mitochondrial inhibitor malonate (MAL) were examined in the rat striatum. MDMA, MAL or the combination of MAL with MDMA was reverse dialyzed into the striatum for 8 h via a microdialysis probe while extracellular dopamine (DA) and serotonin (5-HT) were measured. One we...

background: therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153sm]-samarium maltolate was developed for possible therapeutic applications. materials and methods: the or...

CASE REPORT A 41-year-old female presented to the emergency department with nausea, vomiting and foreign body sensation in her throat. The patient had multiple co-morbidities including hypertension, diabetes, cervical cancer and gastroparesis with gastrojejunostomy (GJ) tube. The patient had stable vitals, was in no respiratory distress, and her only complaint was mild throat pain and abdominal...