Hierarchical clustering algorithms have been studied extensively in the last years. However, existing approaches for hierarchical clustering suffer from several drawbacks. The representation of the results is often hard to interpret even for large datasets. Many approaches are not robust to noise objects or overcome these limitation only by difficult parameter settings. As many approaches heavi...

Scheduling problems play a big role in manufacturing and planning the production for increasing the production efficiency and assigning the resources to operations. Furthermore, in many manufacturing systems there is a physical space between stages that called intermediate buffers. In this study, a model is proposed for minimizing the makespan of a hybrid flow shop scheduling problem with inter...

In this paper, we describe the application of a new type of genetic algorithm called the Structured Genetic Algorithm (sGA) for function optimization in nonstationary environments. The novelty of this genetic model lies primarily in its redundant genetic material and a gene activation mechanism which utilizes a multi-layered structure for the chromosome. In adapting to nonstationary environment...

Multiple signal classification (MUSIC) algorithm has been applied to localize small scatterers for super-resolution imaging. A problem associated with this application is the estimation of the number of scatterers in presence of noise and multiple scattering between targets. In this paper, we show that the mathematical model behind the scattering from the small objects is well compatible with t...

Bacterial cells have evolved a variety of regulatory circuits that tightly synchronize their chromosome replication and cell division cycles, thereby ensuring faithful transmission of genetic information to their offspring. Complex multicomponent signaling cascades are used to monitor the progress of cytokinesis and couple replication initiation to the separation of the two daughter cells. More...

The quality of diverse compound selection mainly depends on cluster algorithms, descriptors, the combinations of the descriptors, and similarity metrics. The Jarvis-Patrick algorithm, MDL search keys, and Daylight fingerprints are a well accepted algorithm and structure descriptors for compound library diversity analysis. Based upon our 288 experiments on selecting compounds from various descri...

The causes of schizophrenia and bipolar human psychiatric disorders are unknown. A novel somatic cell genetic model postulated nonrandom segregation of "Watson" vs. "Crick" DNA chains of both copies of a chromosome to specific daughter cells. Such an oriented asymmetric cell division causes development of healthy, functionally nonequivalent brain hemispheres. Genetic translocations of the chrom...

This study was supported in part by the Dutch ‘Praeventiefonds/ZON9 (Grant 28-3022). We thank Drs. A.W.M. Nieuwint, Y.M. Heins, and K. Madan from the Department of Clinical Genetics and the physicians of the Division of Prenatal Diagnosis of the Department of Obstetrics and Gynecology for their support. We thank Vysis Inc. for their collaboration and for providing the chromosome-specific probes...