spinal cord injury (sci) as a destructive crash result in neurons degeneration. the sci lead to the onset of biochemical and molecular cascades such as inflammation that in turn has a key role in neurodegeneration development. the previous studies demonstrated the role of tnf-α and inos genes in intensifying the process after sci. as a consequence, these genes overexpression intensify the infla...

nitric oxide (no) is thought to be involved in spatial learning and memory in several brain areas such as hippocampus. this study examined the effects of post-training intrahippocampal microinjections of 1400w as a selective inducible nitric oxide synthase (inos) inhibitor on spatial memory, in both anesthetized and non-anesthetized situations in rats. in the present work, 4-day training trials...

CoQ10 and lycopene are isoprenoid compounds with nutraceutical and pharmaceutical benefits. In this study, the effect of concomitant lycopene biosynthesis on CoQ10 accumulation in transformed Escherichia coli DH5α was studied. A lycopene production pathway including geranylgeranyl diphosphate synthase (crtE), phytoene synthase (crtB), and phytoene desaturase (crtI) from Erwinia herbicola was co...

As products of genome mining, the stereochemical assignment macrolide antibiotics stambomycins A–D has been made on basis sequence analysis associated polyketide synthase, aside from...

1, 4, 5, 6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid (ectoine) is an excellent osmoprotectant. ectoine and hydroxyl ectoines are of great significance to the biotechnology industry, thus the detection and isolation of ectoine producing bacteria is of great importance. hence, this study involved the detection of the ectc gene (encoding ectoin synthase enzyme) using polymerase chain reacti...

Mitochondrial ATP synthase is the main enzyme of synthesis. A large number diseases, including neurodegenerative ones, are associated with disorders its assembly and functioning. The aim work to reveal patterns features regional distribution in neurons rat brain structures, a quantitative assessment content at cellular level. study was carried out on material from 5 outbred white male rats. Par...

Mitochondrial activity determines aging rate and the onset of chronic diseases. The mitochondrial permeability transition pore (mPTP) is a pathological in inner membrane thought to be composed F-ATP synthase (complex V). OSCP, subunit synthase, helps protect against mPTP formation. How destabilization OSCP may contribute aging, however, unclear. We have found that loss nematode Caenorhabditis e...

Cytochrome P450 (P450) enzymes are mixed-function oxidases that catalyze the metabolism of xenobiotics and endogenous biochemicals. Selective inhibitors are needed to accurately distinguish the contributions of individual P450 enzymes in the metabolism of drugs and the activation of procarcinogens in human tissues, but very frequently these enzymes have substantial overlapping selectivity. We e...