Burkholderia cenocepacia is a virulent pathogen that causes significant morbidity and mortality in patients with cystic fibrosis (CF), survives intracellularly in macrophages, and uniquely causes systemic infections in CF. Autophagy is a physiologic process that involves engulfing non-functional organelles and proteins and delivering them for lysosomal degradation, but also plays a role in elim...

Discourse markers ('cue words') are lexical items that signal the kind of coherence relation holding between adjacent text spans; for example, because, since, and for this reason are different markers for causal relations. Discourse markers are a syntactically quite heterogeneous group of words, many of which are traditionally treated as function words belonging to the realm of grammar rather t...

Abstract Background: Innate immune myeloid cells, such as macrophages, contribute to chronic inflammation when consistently activated. Recently, cannabidiol (CBD), an active non-psychoactive constituent of the Cannabis sativa plant (i.e., Marijuana), has sparked interest a safe and effective anti-inflammatory immunomodulatory agent. This study aimed investigate CBD’s effects on differentiation ...

A prototype Medical Decision Making System (MDMS) based on a powerful subclass of Artificial Neural Networks (ANNs) and its hardware description using VHDL, is the topic of this article. This MDMS, is generally structured to cover a whole category of distressed body organs. An application on the full spectrum of Pulmonary Diseases (PDs) is presented, whereas the ANNs that compose this MDMS have...

BACKGROUND The levels of proinflammatory cytokine or chemokine in blood and cerebrospinal fluid are thought to be one of predictors for clinical severity of enterovirus 71 (EV71) infection, yet the cellular sources or signalling mechanism remain undefined. Here, we focused on the response of human primary monocyte-derived macrophages (MDMs) to EV71 virus and its possible mechanisms. METHODS H...

Discourse markers (DMs) are linguistic elements that index different relations and coherence between units of talk. Most research on the development of these forms has focused on conversations rather than narratives. This article examines age and medium effects on use of various discourse markers in pre-school children. Fifteen normal Iranian monolingual children, male and female, participated ...

Ideology, power, and identity are truly reflected in people’s daily discourse including mark negotiation discourse of students. Peculiar power relations in Iranian academic settings and the unique features of politeness in Farsi extending up to Ta’arof motivated the researcher to statistically analyze a total of 50 mark negotiation discourse samples of Iranian university students from diverse d...

We evaluated cellular metabolism profiles of HIV-1 and HIV-2 infected primary human monocyte-derived macrophages (MDMs). First, HIV-2 GL-AN displays faster production kinetics and greater amounts of virus as compared to HIV-1s: YU-2, 89.6 and JR-CSF. Second, quantitative LC-MS/MS metabolomics analysis demonstrates very similar metabolic profiles in glycolysis and TCA cycle metabolic intermediat...

Despite the recent attention focused on the roles of the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in the pathogenesis of type 2 diabetes, little is known about the ex vivo profile of inflammasome activation in type 2 diabetic patients. In this study, we investigated patterns of NLRP3 inflammasome activation in monocyte-der...