The aim of this study is to retrospectively analyze the therapeutic effects low-risk invasive mole treatment by methotrexate and summarize high-risk factors which affect chemotherapy outcome. Collect clinical data relationship human chorionic gonadotropin levels largest tumor sizes with cycle toxicity in Zhuzhou Central Hospital from 2015 2020. In study, 42 patients were enrolled All are treate...

Methotrexate is an antineopalstic agent widely used in low dose to treat patients with rheumatoid arthritis. It is known to induce micronuclei at multiple doses in rats. The present study investigates the effect of vitamin A on methotrexate-induced micronuclei in rat bone marrow erythrocytes. Male wistar rats were (n=5) injected with 0, 8, 16 and20mg/kg methotrexate (single i.p dose). A group o...

The efficacy of single-agent chemotherapy for patients with low risk gestational trophoblastic neoplasia (LRGTN) with methotrexate or dactinomycin is well established, but efforts continue to reduce the toxicity, the patients time and cost of treatment. In a randomized clinical trial, we evaluated and compared the efficacy, toxicity and cost effectiveness of pulse-methotrexate versus pulse-dact...

P-glycoprotein (P-gp) overexpression and tumor stem cells are thought to be important factors in the cross-resistance of cancer cells. There have been no studies on whether diallyl trisulfide (DATS) can reverse drug resistance in human osteosarcoma cells. In the present study, we demonstrated that DATS down-regulated P-gp expression and reversed drug resistance. DATS and methotrexate (MTX) decr...

The use of high-volume i.p. chemotherapy with methotrexate (7.5 to 50 microM methotrexate administered via peritoneal dialysis technique) was studied in four patients with ovarian cancer and one patient with malignant melanoma. All had tumor localized to the peritoneal cavity or liver. Methotrexate concentration in the peritoneum could be maintained 18- to 36-fold higher than corresponding plas...

BACKGROUND Chemotherapy is typically used to treat choriocarcinoma, but a small proportion of tumors develop resistance to chemotherapy. Similarly, methotrexate (MTX) is a first-line chemotherapy used to treat choriocarcinoma; although ~30% of patients are drug-resistant for MTX mono-therapy. Thus, we sought to elucidate the mechanism of chemotherapeutic-resistance of MTX. METHODS RNA interfe...

A major issue in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) is resistance to chemotherapeutic drugs. Multidrug resistance can be caused by ATP-binding cassette (ABC) transporters. The majority of these proteins have not yet been examined in T-ALL. Using a newly developed microarray for the simultaneous quantification of 38 ABC transporter genes, we observed a consistent overex...

objective: methotrexate is an antimetabolite drug commonly prescribed for the various cancers and autoimmune diseases. despite its considerable therapeutic effects, nephrotoxicity is the most important side-effect of treatment with methotrexate. aquaporin1 is a water channel proteins which are present in mammalian kidney. raspberry fruit with antioxidant properties is able to protect biological...