Mycoplasma pneumoniae pneumonia (MPP) is a type of induced by M. (MP) infection. The present study investigated the effect long non‑coding RNA growth arrest‑specific 5 (GAS5) in MPP and underlying molecular mechanism this. expression GAS5, microRNA‑222‑3p, (miR‑222‑3p) tissue inhibitor metalloproteinases‑3 (TIMP3) was using reverse transcription‑quantitative PCR. Lipid‑associated m...

Long QT syndrome (LQTS) is a genetic cardiac condition associated with prolonged ventricular repolarization, primarily a result of perturbations in cardiac ion channels, which predisposes individuals to life-threatening arrhythmias. Using DNA screening and sequencing methods, over 700 different LQTS-causing mutations have been identified in 13 genes worldwide. Despite this, the genetic cause of...

Acute kidney injury (AKI) is the most common complication of sepsis. The current incidence sepsis high (0.3% total population) worldwide, and septic AKI may cause death in patients. Long non?coding (lnc)RNAs serve important roles pathogenesis AKI. Therefore, present study investigated mechanism underlying lncRNA plasmacytoma variant translocation 1 (PVT1)?mediated regulation pyroptosis Septic w...

background: early detection is a key to survival for gastric cancer. molecular markers such as mirna (microrna) can have great importance in the early diagnosis of gastric cancer. expression of mir-21 and mir-221 are deregulated in many types of human cancers. this study aimed to investigate the differences in mirna expression patterns within the iranian population. methods: total rna was extra...

Developing new therapeutic strategies which could enhance cardiomyocyte regenerative capacity is of significant clinical importance. Though promising, methods to promote cardiac regeneration have had limited success due to the weak regenerative capacity of the adult mammalian heart. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs, miRs) and long non-coding RNAs (lncRNAs), are functional R...

The aim of the present study is to identify microRNAs (miRs) with high potential to be used as biomarkers in plasma and/or serum to clinically diagnose, or provide accurate prognosis for survival in, patients with atherosclerosis, coronary artery disease, and acute coronary syndrome (ACS). A systematic search of published original research yielded a total of 72 studies. After review of the risk...

conclusions the identified expression profiles of some examined mirnas might offer important points to consider for the treatment of naive patients and the management of chronically infected hcv patients in egypt and around the world. results our results revealed differential expression levels of the analyzed mirnas compared to the normal controls. twenty-seven mirnas (including mir-105, mir-14...

Exosomes are extracellular vesicles that released from most cell types encapsulating specific molecular cargo. serve as mediators of cell-to-cell and tissue-to-tissue communications under normal pathological conditions. It has been shown exosomes carrying muscle-specific miRNAs, myomiRs, secreted skeletal muscle cells in vitro elevated the blood disease patients. The aim this study was to inves...