نتایج جستجو برای: mito mycin c

تعداد نتایج: 1059857  

Journal: :Cancer research 1957
J A DIPAOLO G E MOORE T F NIEDBALA

Actinomycin D has been tested on mouse tu mors, with varying degrees of success, as an anti-neoplastic agent. Dramatic inhibition of some ascites (mouse) tumors has been reported by Sugiura (14) and Gregory et al. (6). Reilly (11) and Sugiura (14) are in agreement that actino-mycin D has slight antineoplastic activity against S-180, and Farber (3) demonstrated antitumor activity against the mal...

2016
Thomas G McWilliams Alan R Prescott George F G Allen Jevgenia Tamjar Michael J Munson Calum Thomson Miratul M K Muqit Ian G Ganley

Autophagic turnover of mitochondria, termed mitophagy, is proposed to be an essential quality-control (QC) mechanism of pathophysiological relevance in mammals. However, if and how mitophagy proceeds within specific cellular subtypes in vivo remains unclear, largely because of a lack of tractable tools and models. To address this, we have developed "mito-QC," a transgenic mouse with a pH-sensit...

2014
Liron Levin Amit Blumberg Gilad Barshad Dan Mishmar

Most cell functions are carried out by interacting factors, thus underlying the functional importance of genetic interactions between genes, termed epistasis. Epistasis could be under strong selective pressures especially in conditions where the mutation rate of one of the interacting partners notably differs from the other. Accordingly, the order of magnitude higher mitochondrial DNA (mtDNA) m...

Journal: :Journal of immunology 2007
Tapan K Mukherjee Anurag K Mishra Srirupa Mukhopadhyay John R Hoidal

In endothelial cells, the intracellular level of glutathione is depleted during offering protection against proinflammatory cytokine TNF-alpha-induced oxidative stress. Administration of anti-inflammatory drugs, i.e., N-acetylcysteine (NAC) or mitoquinone-Q (mito-Q) in low concentrations in the human pulmonary aortic endothelial cells offered protection against depletion of reduced glutathione ...

Journal: :Physiological genomics 2012
Srilatha Sakamuru Xiao Li Matias S Attene-Ramos Ruili Huang Jianming Lu Louie Shou Min Shen Raymond R Tice Christopher P Austin Menghang Xia

Decreases in mitochondrial membrane potential (MMP) have been associated with mitochondrial dysfunction that could lead to cell death. The MMP is generated by an electrochemical gradient via the mitochondrial electron transport chain coupled to a series of redox reactions. Measuring the MMP in living cells is commonly used to assess the effect of chemicals on mitochondrial function; decreases i...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Anissa Igoudjil Jordi Magrané Lindsey R Fischer Hyun Jeong Kim Isabel Hervias Magali Dumont Czrina Cortez Jonathan D Glass Anatoly A Starkov Giovanni Manfredi

Mutations in Cu,Zn superoxide dismutase (SOD1) are associated with familial amyotrophic lateral sclerosis (ALS). Mutant SOD1 causes a complex array of pathological events, through toxic gain of function mechanisms, leading to selective motor neuron degeneration. Mitochondrial dysfunction is among the well established toxic effects of mutant SOD1, but its mechanisms are just starting to be eluci...

Journal: :Cancer research 2017
Claudia Galuschka Rumyana Proynova Benjamin Roth Hellmut G Augustin Karin Müller-Decker

The devastating diseases of human cancer are mimicked in basic and translational cancer research by a steadily increasing number of tumor models, a situation requiring a platform with standardized reports to share model data. Models in Translational Oncology (MiTO) database was developed as a unique Web platform aiming for a comprehensive overview of preclinical models covering genetically engi...

2013
Zhicheng Wang Feng Cai Xiaoyu Chen Meihong Luo Lingling Hu Yuan Lu

A combination of hyperthermia with radiotherapy and chemotherapy for various solid tumors has been practiced clinically. However, hyperthermic therapy has side effects, such as thrombocytopenia. Up to now, the pathogenesis of hyperthermia-induced thrombocytopenia remains unclear. Previous studies have shown that hyperthermia induces platelet apoptosis. However, the signaling pathways and molecu...

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2012
Yuma Yamada Hideyoshi Harashima

Mitochondrial dysfunction has been implicated in a variety of human diseases, including cancer and neurodegenerative disorders. Effective medical therapies for such diseases will ultimately require the targeted delivery of therapeutic agents to mitochondria. This will likely be achieved through innovations in the areas of the nanotechnology of intracellular trafficking. Mitochondrial delivery s...

Journal: :The EMBO journal 2011
Flavie Strappazzon Matteo Vietri-Rudan Silvia Campello Francesca Nazio Fulvio Florenzano Gian Maria Fimia Mauro Piacentini Beth Levine Francesco Cecconi

BECLIN 1 is a central player in macroautophagy. AMBRA1, a BECLIN 1-interacting protein, positively regulates the BECLIN 1-dependent programme of autophagy. In this study, we show that AMBRA1 binds preferentially the mitochondrial pool of the antiapoptotic factor BCL-2, and that this interaction is disrupted following autophagy induction. Further, AMBRA1 can compete with both mitochondrial and e...

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