background: photorefractive keratectomy is a popular mean to correct refractive errors of the eye and haze formation is one of the most important complications of the surgery. although standard dose of intraoperative mitomycin c has shown to be effective in reduction of this complication, potential side effects of mitomycin c promote us to show if the lower concentration of mitomycin c has t he...

We have observed the selective toxicity of mitomycin C toward hypoxic as compared to aerobic cells in vitro for three established cell lines (Chinese hamster ovary, Chinese hamster V-79, and human HeLa) and for cells from the transplantable KHT murine tumor. The magnitude of the selective toxicity was cell line dependent. We have studied the in vivo effects of mitomycin C against aerobic and hy...

Mitochondria-targeted compounds are emerging as a new class of drugs that can potentially alter the pathophysiology of those diseases where mitochondrial dysfunction plays a critical role. We have synthesized a novel mitochondria-targeted esculetin (Mito-Esc) with an aim to investigate its effect during oxidative stress-induced endothelial cell death and angiotensin (Ang)-II-induced atheroscler...

MYCIN was the first large expert system to perform at the level of a human expert and to provide users with an explanation of its reasoning. Most expert systems developed since MYCIN have used MYCIN as a benchmark to define an expert system. Moreover, the techniques developed for MYCIN have become widely available in the various small expert system building tools. MYCIN was developed at Stanfor...

MYCIN was the first large expert system to perform at the level of a human expert and to provide users with an explanation of its reasoning. Most expert systems developed since MYCIN have used MYCIN as a benchmark to define an expert system. Moreover, the techniques developed for MYCIN have become widely available in the various small expert system building tools. MYCIN was developed at Stanfor...

Paclitaxel is an antimicrotubule agent that induces mitotic block and apoptosis. We show for the first time that paclitaxel acts directly or mitochondria isolated from human cancer cells. In isolated yeast mito chondria, paclitaxel (15 microM) induced an 18% increase in the respiration rate, with no concomitant release of cytochrome c. In isolated neuroblas toma mitochondria, paclitaxel (10-100...

Background: Most of the cytogene c dosimetry, except Premature Chromosome Condensa on assay, saturates at 6 Gy. Present studies are aimed to assess feasibility of simple CB‐MN assay for prescreening of high dose accidental exposures. Materials and Methods: Human peripheral blood lymphocytes from two donors were gamma irradiated to different doses ranging from 0‐15Gy, cultured for 72 h. Cytochal...

Colistin methanesulfonate (CMS) has the potential to hydrolyze in aqueous solution to liberate colistin, its microbiologically active and more toxic parent compound. While conversion of CMS to colistin in vivo is important for bactericidal activity, liberation of colistin during storage and/or use of pharmaceutical formulations may potentiate the toxicity of CMS. To date, there has been no info...