ESX-5 is one of the five type VII secretion systems found in mycobacteria. These secretion systems are also known as ESAT-6-like secretion systems. Here, we have determined the secretome of ESX-5 by a proteomic approach in two different strains of Mycobacterium marinum. Comparison of the secretion profile of wild-type strains and their ESX-5 mutants showed that a number of PE_PGRS and PPE-MPTR ...

background: the risk of developing tuberculosis is high among chronic hemodialysis patients. the tuberculin skin test (tst) has been in use for diagnosing latent tb, but few data are available on tst in hemodialysis patients. objective: this study was done to identify the tst reactivity and frequency of booster effect in serial tst among hemodialysis patients. methods: a total of 100 patients i...

Tuberculosis is one of the leading infectious causes death in adults worldwide. The human host acts as a natural reservoir for Mycobacterium tuberculosis. Pregnancy carries an increased risk infections.

introduction mycobacterium tuberculosis complex (mtbc) are causative agents of human and animal tuberculosis.differentiation of mtbc members is required for appropriate treatment of individual patients and for epidemiologicalpurposes and reduction in drug resistances. material and methods 1345 patients were collected with clinical suspicions of tuberculosis who referred to the health care cente...

background : despite recent technologic improvements in identifying mycobacterium tuberculosis, we are still facing problems in rapid diagnosis of tuberculosis. the objective of this study is to determine the diagnostic value of a new rapid screening test (patho-tb™) for diagnosis of pulmonary tuberculosis. methods : between september 2006 to august 2007, 178 patients were enrolled in the study...

background tuberculosis (tb) continues to be a major public health problem worldwide. in developing countries, the burden of the disease is explosive, as 95% of global tb patients reside and 98% of global tb deaths occur in these regions. patients’ satisfaction may play a major role in adherence to medications and hence improve tuberculosis cure rate. objectives the current study aimed firstly ...

Several reports have indicated that infection with Non-Tuberculosis Mycobacteria (NTM) is increasing worldwide.Therefore,monitoring species causing micobacterial infection in any region is of great importance. This study was going to detect, differentiate, and identify pathogenic mycobacteria in primary clinical samples. Eighty samples collected from tuberculosis suspected patients in Isfahan/I...

Tuberculosis and smoking are among the most pressing issues in modern health care system world. patients who smoke confirmed to have reduced effectiveness of anti-tuberculosis therapy, unsatisfactory prognosis a specific disease, higher risk treatment failure mortality from this disease. Diseases such as HIV alcoholism increase ineffective tobacco smokers. In addition, leads increased virulence...