INTRODUCTION Sarcoidosis is a systemic granulomatous disorder thought to be an exaggerated immune response to unknown antigens. It often presents with bilateral mediastinal lymphadenopathy and/or pulmonary infiltrates (1). Sarcoidosis has been found in association with a variety of malignancies, including malignant myeloproliferative disorders (2). To date, only two cases of acute myeloblastic ...

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell disorder in which the blood cells demonstrate aberrant interactions with serum complement. In part, this is due to the absence of the complement regulatory protein, decay accelerating factor (DAF). A small number of patients with PNH have gone on to develop acute nonlymphocytic leukemia, which is thought to arise f...

N ORMAL granulocytes, monocytes, and erythrocytes are derived from small numbers of bone marrow progenitor cells that have extensive proliferative capacity. 3 In vitro cell culture techniques to identify progenitor cells have been available for 20 years and depend on the ability of these cells to form colonies of fully differentiated cells in semisolid medium in response to specific growth fact...

The introduction of combination chemotherapy in the treatment of adult acute leukemia has had a profound impact on the response and duration of survival of patients with adult acute myeloblastic leukemia. In the past decade, the combination of cytosine arabinoside with an anthracycline antibiotic, either daunorubicin, adriamycin, or rubidazone, has been responsible to a large degree for the suc...

Two patients with acute myeloblastic leukemia (AML) with double minute chromosomes (dmins) are described. One patient had dmins in approximately one-third of bone marrow cells examined at diagnosis; no other karyotypic changes were observed. The dmins disappeared when the patient achieved a complete remission. The second patient developed acute leukemia as a second cancer, having previously rec...