Fifteen cases (3.1%) of localized myeloblastic tumors occurring among 478 patients with acute granulocytic leukemia (AG 1) and chronic granulocytic leukemia (CGL) are described. The majority of tumors were discovered at autopsy. Numerous cases of chloroma associated with AG L have been reported; however, in this series, the incidence of myeloblastic tumors in CGL was twice as high. The importan...

Daunorubicin has been used in the treatment of six cases of acute lymphoblastic and thirteen cases of acute myeloblastic and mono-myeloblastic leukaemia. Complete remissions were obtained in eight patients, three with acute lymphoblastic leukaemia and five with acute myeloblastic leukaemia. Marrow aplasia makes the drug difficult to administer, but no patients died from this cause, in this seri...

acute myeloblastic leukemia is one of the important malignancies in children. for better managing the prognosis of this disease, there should be enough information about common features of this malignancy. the aim of this study was to evaluate these common features in children with acute myeloblastic leukemia. a total of 104 eligible children less than 15-year-old have been referred from 2007-2...

Background: In acute myeloblastic leukemia, a large number of tumor suppressor genes are silenced through DNA methylation such as CDKN2B & p73. Wnt inhibitory factor 1 (WIF1) and Dickkopf-3 (DKK-1) are negative regulators of Wnt signaling pathway. In the present study, we evaluated the methylation status of WIF1 and DKK-1 genes in acute myeloblastic leukemia patients. Patients and Methods: ...

I N CHRONIC GRANULOCYTIC LEUKEMIA neurologic manifestations due to leukemic infiltration of the central nervous system occur uncommonly.’ In acute lymphoblastic leukemia, on the other hand, diffuse leukemic infiltration of the lepto-meninges is frequent and must be differentiated from neurologic involvement due to infection, hemorrhage, or drug toxicity.2 \Vhen acute myeloblastic transformation...

nicious anemia and polycythemia, or of pernicious anemia and acute myeloblastic leukemia, is extremely rare. Wintrobe’ notes only four instances imi which pernicious anemia preceded the onset of acute myeloblastic leukemia. Polycythemia following pernicious anemia is of equal rarity.’ ‘ 2 On the other hand, the emergence of acute leukemia in cases of polycythemia, while uncomiimon, is miot as r...

Acute myeloblastic leukemia accounts for approximately 20% of acute leukemias in children. The days the microscope represented the main tool in the diagnosis and classification of Acute Myeloblastic Leukemia seem to be very far. This review summarizes the current diagnosis of this malignancy, where the morphological, cytochemical, immunophenotyping, cytogenetic and molecular characterization re...