INTRODUCTION Encapsulation of biologically active molecules into nanoparticles (NPs), for site-specific delivery, is a fast growing area. These NPs must be biocompatible, non-toxic, and able to release their load in a controlled way. We have developed a series of NPs based on (bio)degradable and biocompatible poly(malic acid) derivatives, poly(benzyl malate) (PMLABe), with its PEG-grafted steal...

Chemotherapeutic agents lead to the damage of healthy cells because they react with cells which are dividing at a high rate by inhibiting the DNA synthesis and interfering with the process of cell division. "Therapeutic drug delivery allows for an increase in the efficacy of the chemotherapeutic agent while minimizing the interaction with nontumour sites in the body by controlling the release r...

Dissipative particle dynamics simulations were used to study the effects of mixing time, solute solubility, solute and diblock copolymer concentrations, and copolymer block length on the rapid coprecipitation of polymer-protected nanoparticles. The simulations were aimed at modeling Flash NanoPrecipitation, a process in which hydrophobic solutes and amphiphilic block copolymers are dissolved in...

This research describes the role of starch nanoparticles in stabilizing surfactant-free emulsion, namely Pickering emulsion. However, concentration and NaOH during preparation as a emulsifier have not been studied. Thus, this study aimed to obtain proper concentrations when preparing breadfruit-based emulsifiers for varied (1, 3,or 5 (%(w/v)) (0.1875 0.375 M) form dispersion. Starch were acquir...

Ferroelectric polymer nanoparticles of poly(vinylidene fluoride) (PVDF) were prepared by dialysis nanoprecipitation. Particles with mean diameter 230 nm show piezoelectric response as observed Piezoresponse Force Microscopy (PFM). The origin this ferroelectric behavior has been attributed to the presence ferroelectrically active crystalline phases PVDF in (mainly ? and ? phases) demonstrated di...