In this study, we prepared all-trans retinoic acid (ATRA)-encapsulated, surfactant-free, PLGA nanoparticles. The nanoparticles were formed by nanoprecipitation process, after which the solvent was removed by solvent evaporation or dialysis method. When a nanoparticle was prepared by the nanoprecipitation solvent evaporation method, the nanoparticles were bigger than the nanoparticles of the nan...

PURPOSE Nanoprecipitation is the convenient and commonly used method for the preparation of polymeric nanoparticles around 170 nm but yield particles with broad distribution, which require filtration step to produce particles with narrow distribution. Hence, the primary aim of the present study was to implement few modifications to the conventional nanoprecipitation method to reduce the mean pa...

One of the first methods to encapsulate drugs within polymer nanospheres was developed by Fessi and coworkers in 1989 and consisted of one-step nanoprecipitation based on solvent displacement. However, proteins are poorly encapsulated within polymer nanoparticles using this method because of their limited solubility in organic solvents. To overcome this limitation, we developed a two-step nanop...

We here report an easy and efficient strategy to prepare submicron-sized polymeric vesicles with tetrahydrofuran (THF) as a good solvent through temperature-assisted nanoprecipitation (TAN). While conventional nanoprecipitation did not yield vesicles from block co-polymers (PEG-b-PCL), TAN produced vesicles with morphology and membrane thickness similar to those obtained by film rehydration met...

We report the use of microfluidic rapid mixing using hydrodynamic flow focusing to control the self-assembly of polymeric nanoparticles (NPs) that can be used for drug delivery. PLGA-PEG polymeric NPs and PLGA-lipid hybrid NPs were synthesized through nanoprecipitation—a process that involves dilution of a block copolymer from a solvent to an anti-solvent resulting in the precipitation of NPs. ...

Biodistribution of nanoparticle-based intracellular delivery systems is mediated primarily by particle size and physicochemical properties. As such, overcoming the rapid removal of these by the reticuloendothelial system remains a significant challenge. To date, a number of copolymer nanoparticle systems based on 2-methacryloyloxyethyl phosphorylcholine (MPC) with 2-(diisopropylamino)ethyl meth...

Paclitaxel-polylactide (Ptxl-PLA) conjugate nanoparticles, termed as nanoconjugates (NCs), were prepared through Ptxl/(BDI)ZnN(TMS)(2) (BDI = 2-((2,6-diisopropylphenyl)-amido)-4-((2,6-diisopropylphenyl)-imino)-2-pentene)-mediated controlled polymerization of lactide (LA) followed by nanoprecipitation. Nanoprecipitation of Ptxl-PLA resulted in sub-100 nm NCs with monomodal particle distributions...

We demonstrated a one-pot, soap-free fabrication of porous polycaprolactone microspheres by combining nanoprecipitation and hydrolysis. The obtained porous polycaprolactone microspheres show great advantages for application in drug delivery.

To establish a satisfactory delivery system for the delivery of salinomycin (Sal), a novel, selective cancer stem cell inhibitor with prominent toxicity, gelatinase-responsive core-shell nanoparticles (NPs), were prepared by nanoprecipitation method (NR-NPs) and single emulsion method (SE-NPs). The gelatinase-responsive copolymer was prepared by carboxylation and double amination method. We stu...

Paclitaxel dimer-based nanovesicles, with an ultrahigh drug content, have been prepared through a nanoprecipitation method. The as-formed nanovesicles exhibit improved paclitaxel solubility, prominent colloid stability, GSH-triggered disassembly, effective cellular uptake and comparable cytotoxicity to Taxol.