Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease...

Due to vigorous alloimmunity, an allograft is usually rejected without any conventional immunosuppressive treatment. However, continuous global immunosuppression may cause severe side effects, including tumors and infections. Mounting evidence has shown that cyclosporine (CsA), a common immunosuppressant used in clinic, impedes allograft tolerance by dampening regulatory T cells (Tregs), althou...

created. Nevertheless, methods do exist to induce and expand natural Tregs in vitro, for example, with anti-CD3 TGF ,8 albeit the plasticity of these cells is a concern.9 The specificity of these Tregs needs to be tightly determined and controlled. Otherwise, we will be creating an expensive and nonspecific immunosuppressive cellular therapy. Despite these caveats, this model offers promise tha...

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Regulatory T-cells (Tregs) are a subset of T cells generated in the thymus with intrinsic immunosuppressive properties. Phase I clinical trials have shown safety and feasibility Treg infusion to promote immune tolerance new studies ongoing evaluate their efficacy. During heart transplantation, thymic tissue is routinely discarded providing an attractive source Tregs. In this study, we developed...

evant antigen. These data suggest a model in which populations of tissue-specifi c Tregs arise during thymic development and then accumulate within those peripheral tissues on the basis of antigen recognition (see the fi gure). As tumors develop, these preexisting tissue-resident Tregs are recruited into and/or expanded within the tumor microenvironment, potentially allowing them to exert local...

Antibody-mediated rejection (AMR) has emerged as the major cause of renal allograft dysfunction, and more effective strategies need to be explored for improving transplant outcomes. Regulatory T cells (Tregs), consisting of at least natural and induced Treg subsets, suppress effector responses at multiple levels and play a key role in transplantation tolerance. In this study, we investigated th...