purpose: to report two patients with keratoconus who underwent regrafting to correct anisometropia and high astigmatism after penetrating keratoplasty. patients and findings: the first case is a 34-year-old man with keratoconus who had undergone penetrating keratoplasty. the sutures were removed 6 months postoperatively that led to high hyperopia. regraft was performed considering vitreous leng...

PURPOSE Stem and progenitor cell transplantation provides a promising clinical application for treating degenerative retinal diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Our previous studies have shown that a single subretinal injection of human cortical-derived neural progenitor cells (hNPCctx) into cyclosporine-treated Royal College of Surgeons (RC...

Studies of neural cell transplantation would be aided by the ability to damage or destroy, noninvasively and extremely selectively, grafted cells at defined times following their initial implantation. Mechanisms of graft integration and performance could be investigated, also providing insight into natural injury and repair mechanisms. At long wavelengths between 650 and 850 nm, laser energy ca...

According to a recent model, the cortical tractor model, neural fold and neural crest formation occurs at the boundary between neural plate and epidermis because random cell movements become organized at this site. If this is correct, then a fold should form at any boundary between epidermis and neural plate. To test that proposition, we created new boundaries in axolotl embryos by juxtaposing ...

Trakhtenbrot L, et al. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain. Abramsky O, et al. Intraventricular tra...

High-level spinal cord injury can lead to cardiovascular dysfunction, including disordered hemodynamics at rest and autonomic dysreflexia during noxious stimulation. To restore supraspinal control of sympathetic preganglionic neurons (SPNs), we grafted embryonic brainstem-derived neural stem cells (BS-NSCs) or spinal cord-derived neural stem cells (SC-NSCs) expressing green fluorescent protein ...

The expression of soluble growth and survival promoting factors by neural precursor cells (NPCs) is suggested to be a prominent mechanism underlying the protective and regenerative effects of these cells after transplantation. Nevertheless, how and to what extent specific NPC-expressed factors contribute to therapeutic effects is not well understood. Using RNA silencing, the current study inves...

conclusions our study showed that desmopressin could not reduce the amount of blood loss after cabg. also, desmopressin did not have a significant effect on coagulation status. therefore, based on the results of our study, it seems that the use of this medication cannot be a helpful for patients with any indication for cabg. background coronary artery bypass grafting (cabg) is a common surgical...

background although the immunosuppressant cyclosporine (csa) is widely used after kidney transplantation over the long term, there is still no firm consensus on the best way to monitor of csa blood levels. objectives cyclosporine (csa) assay is critical for the management of renal transplant recipients due to inter– and intra–patient variation in csa absorption and metabolism. patients and meth...