To the Editor:—Schreiber et al. noted an association between larger doses of succinylcholine and a reduced incidence of fasciculation and myalgia. However, pretreatment with a nondepolarizing neuromuscular blocker is also associated with a reduced risk of fasciculation and myalgia. It is a common practice for clinicians to use a larger dose of succinylcholine when they have provided pretreatmen...

It is often argued that neuromuscular monitoring is unnecessary when only one dose of an intermediate-acting neuromuscular blocking agent is given. This case report documents that it may take more than 3.5 h before it is possible to antagonize a block caused by a normal dose of rocuronium (0.6 mg kg(-1)). Possible causes of the extremely prolonged duration of action are discussed, as is the imp...

Neuromuscular-blocking agents (NMBA) have been used in clinical anesthesia for nearly 60 years. In the perioperative period, a variety of factors can influence a patient’s response to these drugs. To precisely titrate NMBAs to clinical effects in the anesthetized patient, the application of neuromuscular monitoring is essential. The use of a peripheral nerve stimulator allows the clinician to a...

D,uke-Elder and Duke-Elder first re ported on the action of choline and nicotine on the mammalian extraocular muscle; this was followed by a study by Brown and Harvey on the cat extrinsic eye muscle. Since then very little investigation has been reported on mammalian extraocular muscle, except by Breinin. Recently, more detailed investigation of cat extraocular muscle has been reported followin...

The relative potency, time-course of action and cardiovascular effects of Org NC 45, a new non-depolarizing neuromuscular blocking agent, have been compared with those of pancuronium, alcuronium and tubocurarine in 64 anaesthetized patients. The relative potency (ED50) to Org NC 45 was 1.74, 3.69 and 8.57 respectively. In doses which caused useful surgical relaxation, duration of action of Org ...