Organic nitrates undergo enzymatic metabolization in the vasculature to release the active compound nitric oxide (NO). The resulting preferential venodilation has been suggested to be related to the vascular bioactivation process of organic nitrates because sodium nitroprusside, which is bioactivated differently, is not venoselective. We sought to determine whether NO has an influence on vascul...

INTRODUCTION AND OBJECTIVES There is little evidence on the prognostic influence of intravenous nitrates in patients with acute heart failure. Our purpose was to determine the influence of this treatment on early mortality and new visits. METHODS Prospective, multicenter cohort study of patients with acute heart failure in an emergency room during 2 periods (May 2009 and November-December 201...

INTRODUCTION An excess of nitrates causes environmental pollution in receiving water bodies and health risk for human, if contaminated water is source of drinking water. The directive 91/676/ CEE [1] aims to reduce the nitrogen pressure in Europe from agriculture sources and identifies the livestock population as one of the predominant sources of surplus of nutrients that could be released in w...

AIMS Protocols using sublingual nitrates have been increasingly used to improve diagnostic accuracy of head-up tilt testing (HUT). Nevertheless, exaggerated responses to nitrates have been frequently described, particularly in elderly patients. The aim of this article is to evaluate, in an elderly population with unexplained syncope, whether the impact of sublingual nitroglycerin (NTG) used as ...

OBJECTIVE Reduced levels and impaired function of endothelial progenitor cells (EPCs) foster development and progression of atherosclerotic lesions. Endothelial nitric oxide synthase (eNOS)-derived NO regulates EPC mobilization and function. Organic nitrates release NO, and therefore may favorably affect EPC biology. METHODS AND RESULTS We compared the effects of 2 different nitrates on circu...

Application of thermal dissociation-laser induced fluorescence (TD-LIF) to measurement of HNO3, Σalkyl nitrates, Σperoxy nitrates, and NO2 fluxes using eddy covariance D. K. Farmer, P. J. Wooldridge, and R. C. Cohen Department of Chemistry; University of California, Berkeley, CA, 94720, USA Dept. of Earth and Planetary Science; University of California, Berkeley, CA, 94720, USA Received: 22 Dec...