Sublingual glyceryl trinitrate (nitroglycerin) is the most widely used drug in the treatment of angina pectoris, but its use is limited due to its short acting effect. Recent investigations have shown that some longer acting nitrates administered orally or topically have a long acting antianginal effect. The mechanism of the antianginal effect of nitrates is multifactorial. Nitrates increase ox...

Stressful growing conditions often result in high concentrations of nitrates in plant tissue. When feeding animal forages containing toxic levels of nitrates, poor productivity or death may occur. This publication summarizes the effect that high nitrates have on the animal, presents the conditions to expect in toxic concentrations of nitrates, and outlines strategies that could prevent or reduc...

Alkyl and multifunctional organic nitrates, molecules of the chemical form RONO2, are products of chain terminating reactions in the tropospheric HOx and NOx catalytic cycles and thereby impact ozone formation locally. Many of the molecules in the class have lifetimes that are long enough that they can be transported over large distances. If the RONO2 then decompose to deliver NOx to remote reg...

conclusions in conclusion, the electrocoagulation process can be used for removing nitrate from water resources because of high efficiency, simplicity, and relatively low cost. results results of the present study showed that the removal efficiency was increased from 27% to 86% as ph increased from 3 to 11 at the optimal condition of 30 v and 75 min operation time. moreover, by increasing the r...

[1] The formation of organic nitrates during the oxidation of the biogenic hydrocarbon isoprene can strongly affect boundary layer concentrations of ozone and nitrogen oxides (NOx = NO + NO2). We constrain uncertainties in the chemistry of these isoprene nitrates using chemical transport model simulations in conjunction with observations over the eastern United States from the International Con...

This of pape Add Chicag 1 Pre Abstract—Nitroglycerine has been used clinically in the treatment of angina for 130 years, yet important details on the mechanism of action, biotransformation, and the associated phenomenon of nitrate tolerance remain unanswered. The biological activity of organic nitrates can be said to be nitric oxide mimetic, leading to recent, exciting progress in realizing the...

Background. The present study was designed to investigate the intracellular production of cyclic GMP (cGMP) in platelets in response to nitroglycerin and to determine the potential clinical value of platelet cGMP as an indicator of the effects of nitroglycerin and nitrate tolerance. Methods and Results. Platelet cGMP levels and the diameters of the coronary arteries before and 2 minutes after i...

Background. The present study was designed to investigate the intracellular production of cyclic GMP (cGMP) in platelets in response to nitroglycerin and to determine the potential clinical value of platelet cGMP as an indicator of the effects of nitroglycerin and nitrate tolerance. Methods and Results. Platelet cGMP levels and the diameters of the coronary arteries before and 2 minutes after i...