This study investigates the vasomotor activities of prostaglandin (PG) D2 in bovine coronary arteries in relation to endothelial function. Isolated segments of bovine coronary arteries with intact endothelium were concentration-dependently relaxed by PGD2 (0.01-1 microM), a reaction that was blocked by a selective PGD receptor antagonist (BW A868C). There was a tight correlation between PGD2- a...

increased nitric oxide (no) formation is mechanistically linked to pathophysiology of the extrahepatic complications of cirrhosis. no is formed by either enzymatic or non-enzymatic pathways. enzymatic production is catalyzed by no synthase (nos) while entero-salivary circulation of nitrate and nitrite is linked to non-enzymatic formation of no under acidic ph in the stomach. there is no data on...

abstract introduction: matrix metalloproteinase 2 is one of the inflammatory mediators that is involved in nociceptive processing and its production is regulated by many inflammatory factors such as nitric oxide. we studied the role of mmp-2 on the analgesic effects of nnos inhibitor. methods: considering that nitric oxide has many roles in pain processing, we studied the csf levels of mmp-2 af...

introduction: cigarette smoking affects nitric oxide production. the aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (nox) concentration. methods: serum nox concentration was measured by the griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. subjects were selected from participants of tehran lipid and gluco...

introduction: several investigations have indicated that dopamine d receptors could influence morphine 2 eward. the influence of olanzapine (a d dopamine receptor antagonist) on the morphine-induced conditioned 2 lace preference (cpp) in male and female mice was investigated in the present study. methods: the effects of olanzapine on the acquisition and expression of morphine cpp in male and fe...

nitric oxide (no) is an important molecule synthesized during wound repair. studies have reported the use of no donors on cutaneous wound repair, but their effects in different phases of healing are not elucidated. the aim of this work was to investigate the effects of topical sildenafil on wounds in rats. sildenafil (25 mg) was topically applied once daily on wound in treatment groups. on days...

BACKGROUND AND PURPOSE Endothelial nitric oxide synthase produces superoxide under physiological conditions leading to hydrogen peroxide (H(2)O(2)) -dependent dilations to acetylcholine in isolated mouse cerebral arteries. The purpose of this study was to investigate whether H(2)O(2) was involved in flow-mediated dilation (FMD). METHODS Cerebral arteries were isolated from 12+/-2-week-old C57...

cosmic rays in the upper troposphere (9000 meters to 15000 meters) initiate the followingnuclear chemical reaction: 1n + 14n => 14c + 1h. previous research has shown a strong effect of latitude onthe abundance of neutrons from cosmic rays. however, to date, there has been little exploration of therelationship between the latitude effect for cosmic-ray neutrons and latitudinal variations of stab...

abstract background: pressure ulcer is one of the main concerns of nurses in medical centers around the world, which, if untreated, causes irreparable problems for patients. in recent years, nitric oxide (no) has been proposed as an effective method for wound healing. this study was conducted to determine the effect of nitric oxide on pressure ulcer healing. materials and methods: in this clini...