Pre-treatment with new kynurenic acid amide dose-dependently prevents the nitroglycerine-induced neuronal activation and sensitization in cervical part of trigemino-cervical complex. Kynurenate derivative attenuates the nitroglycerin-induced CamKIIalpha and CGRP expression changes. Modulatory effects of probenecid on the nitroglycerin-induced changes in the rat caudal trigeminal nucleus. Migrai...

background: recent studies of uterine contractility in ivf�embryo transfer led us to consider an alternative, and possibly complementary, explanation for the high implantation rates of blastocysts. it has been demonstrated that myometrial contractile activity influences embryo implantation, possibly through mechanical displacement of embryos. objective: the aim of this study was to examine the ...

We describe a case of a 68-year-old man with known ischaemic heart disease, who passed out after nitroglycerine administration. He had triple-vessel ischaemic heart disease and had suffered from myocardial infarction about 17 years prior to this incident. An ECG revealed ST-segment elevation in the anterior leads. The elevations lasted at least 40 minutes and no longer than 60 minutes. No tropo...

BACKGROUND Under certain conditions, exertional headaches may reflect coronary ischemia. CASE REPORT A 44-year-old woman developed intermittent exercise-induced headaches with chest tightness over a period of 10 months. Cardiac catheterization followed by acetylcholine provocation demonstrated a right coronary artery spasm with chest tightness, headache, and ischemic effect of continuous elec...

Relief of angina by nitroglycerine has been attributed to two possible mechanisms: (1) Increase in myocardial blood supply by direct acton of the drug on the coronary arteries. (2) Reduction in myocardial oxygen demand by action of the drug on the systemic circulation. Sublingual application of nitroglycerin in previous studies did not allow the ruling out of the operation of either or both mec...