OBJECTIVE Nitroglycerine-induced vasodilation has been used as a control test for flow-mediated vasodilation (FMD) to differentiate endothelium-dependent from endothelium-independent response when evaluating endothelial function in humans. Recently, nitroglycerine-induced vasodilation has also been reported to be impaired in patients with atherosclerosis. The purpose of this study was to determ...

UNLABELLED Measurement of nitroglycerine-induced vasodilation has been performed to differentiate endothelium-dependent vasodilation from endothelium-independent vasodilation as a control test for flow-mediated vasodilation (FMD). Recently, nitroglycerine-induced vasodilation per se has been reported to be a useful marker of the grade of atherosclerosis. The present study aimed to evaluate the ...

Continuous treatment with organic nitrates causes nitrate tolerance and endothelial dysfunction, which is involved with protein kinase C (PKC) signal pathway and NADPH oxidase activation. We determined whether chronic administration with nitroglycerine compromises the protective effects of propofol against tumor necrosis factor (TNF-) induced toxicity in endothelial cells by PKC- β2 dependent N...

OBJECTIVE The aim of this study was to determine whether or not heart rate variability (HRV) analysis during the first 20 min of head-up tilt testing could predict whether patients will develop syncope after nitroglycerine administration. DESIGN 64 patients with previous loss of consciousness underwent head-up tilt testing with the Italian protocol, which involves the administration of nitrog...

INTRODUCTION AND OBJECTIVE Transrectal ultrasound biopsy of prostate is a painful procedure. The introduction of the rectal probe is one of the major contributors to the pain associated with this procedure. Drugs that relax the anal sphincter should theoretically decrease this pain. This study was done to compare the efficacy and safety of two topical medications that relax the anal sphincter, ...

BACKGROUND AND PURPOSE It has been suggested that off-label use of transdermal nitroglycerine patches to prevent frostbite may lead to severe acute mountain sickness and ataxia. The aim of this study was to investigate the effect of nitroglycerine on brain vascular permeability by using dynamic contrast-enhanced MR imaging in a swine model. MATERIALS AND METHODS Eight Danish Landrace-Yorkshir...

In our study, the beneficial effects of locally applied nitroglycerine on the ease of cannulation were confined to children younger than 1 year, whereas no significant benefit was found in older children. On the other hand, no significant difference in venous status was apparent, even in younger patients. The lack of efficacy of nitroglYcerine in group 3 patients indicates local action of this ...

The life of 19th century Swedish chemist cum inventor Alfred Nobel can be conveniently divided into two equal phases: pre-nitroglycerine phase (1833-1863) and nitroglycerine phase (1864-1896). According to the records of Ragnar Sohlman, his assistant during his last year of life, Nobel's physical condition began to decline towards the end of the 1870s, and for the last 16 years he suffered from...

It is suggested that sublingual nitroglycerine can improve the ability of T1-201 for detection of viable myocardium. Methods and Results: In a randomized, double blind study, 50 patients who had fixed defects on stress-redistribution scan, were randomized into two groups. In group I, patients received 0.4-0.8 mg sublingual nitroglycerine, before T1-201 reinjection. In group II, reinjectio...