Cholesterol efflux (ChE) from macrophages is an initial step of reverse cholesterol transport (RCT). The ATP-binding cassette transporter A1 (ABCA1) is a key transporter for ChE and its increased expression is regarded to attenuate atherosclerosis. Thus, the identification and characterization of molecules raising ABCA1 and thereby stimulating ChE is of pharmacological relevance. In this study,...

Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a triterpenoid acid derived synthetically from glycyrrhetinic acid, has been characterized as a peroxisome proliferator-activated receptor γ agonist with a broad range of receptor-dependent and -independent anticancer activities. Although CDODA-Me decreases the expression of some angiogenic genes in cancer cells, the direct effect...

The phytochemical study of Dorstenia arifolia Lam. (Moraceae) has led to the identification of 18 triterpenes esterified by fatty acids, five triterpenes without esterification, 12 triterpenes esterified by acetic acid, together with a known furanocoumarin: α-amyrin (1), β-amyrin (2) α-amyrin acetate (3) β-amyrin acetate (4), α-amyrin octanoate (5), β-amyrin octanoate (6), α-amyrin decanoate (7...

Plants belonging to the Weigela genus are traditionally used flourish gardens, homes, and other living areas. This contains ten species that mainly found in Asia, but many cultivars have been cultivated around world. Previous studies on some of this revealed occurrence triterpenoid saponins, which possess interesting biological activities such as cytotoxicity, anti-complementary activity, anti-...

Chi Weigela, thuộc họ Kim ngân (Caprifoliaceae) có vùng phân bố rộng trên thế giới, với hơn 200 loài đã được lai tạo phục vụ cho mục đích làm cảnh và dùng thuốc. W. florida “Jean’s Gold” là cây dạng bụi, trồng tại châu Âu do màu sắc hoa đẹp dễ phát triển. Từ cao chiết ethanol của phần rễ Florida Gold”, bằng các phương pháp ký khác nhau, kết hợp phổ hiện đại, nghiên cứu lập xác định cấu trúc 2 c...

Acyl-coenzyme A (CoA):cholesterol acyltransferase (ACAT) catalyzes the intracellular fatty acid esterification of cholesterol and is thought to play a key role in lipoprotein metabolism and atherogenesis. Herein we describe the purification and characterization of a novel pentacyclic triterpene ester from rabbit liver that has ACAT inhibitory activity. The inhibitor was purified by a combinatio...