نتایج جستجو برای: onset type eoad
تعداد نتایج: 1494578 فیلتر نتایج به سال:
BACKGROUND Alzheimer's disease (AD) is one of the most common problems for old peoples. Etiology of AD is not clear, but genetic factors play a major role in determining a person's risk to develop AD. Twin and family studies confirm that AD has a genetic basis. AD genetics has been split into two broad categories: early-onset and late-onset. EOAD cases are inherited in an autosomal dominant pat...
The 3D amygdalar shape was reconstructed with the Radial Atrophy Mapping technique, based on manual segmentations [3]. Shape differences between EOAD and LOAD patients and their age-matched control group were investigated. Permutation testing was used to correct the statistical maps for multiple comparisons [3]. A 3D amygdala model constructed from histological sections was used to infer which ...
alzheimer’s disease (ad) is the most common cause of dementia caused by complicated interactions between genetic and environmental factors. molecular genetic research has provided valuable information regarding the genetic etiology of the disease. identifying the genetics of ad not only could shed light on disease pathogenesis, but it may also provide potential targets for effective treatment, ...
the present research study attempted to find out the extent to which two pre-task activities of “glossary of unknown vocabulary items” and “content related support” assisted efl language learners with their performance on listening comprehension questions across two different proficiency levels (low and high). data for this study were obtained from a total of 120 language learners, female and m...
Background and Aim: Psoriasis is a chronic papulosquamous disorder, which affects about 2% of the population. Psoriasis is relatively common in childhood: more than 10% of cases start before the age of 10. Tha aim of this study was to compare the clinical characteristics between pediatric-onset and adult-onset psoriasis in Iranian patients. Methods: In 2006 and 2007, clinical data were coll...
the prevalence of type 2 diabetes mellitus (t2dm) is rising dramatically in the middle east, especially in the islamic republic of iran, but the genetic basis of type 2 diabetes in iran is poorly understood. polymorphisms of hepatocyte nuclear factor-1α (hnf-1α) and glucagon-like peptide-1 receptor (glp-1r) genes showed association with type 2 diabetes in several ethnic groups. in this study, w...
BACKGROUND Although many studies have estimated the association between the butyrylcholinesterase (BCHE) K variant and Alzheimer's disease (AD) risk, the results are still controversial. We thus conducted this meta-analysis. MATERIAL/METHODS We searched NCBI, Medline, Web of Science, and Embase databases to find all eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were ...
Mitochondrial dysfunction has been thought to contribute to Alzheimer disease (AD) pathogenesis through the accumulation of mitochondrial DNA mutations and net production of reactive oxygen species (ROS). Mitochondrial cytochrome c-oxidase plays a key role in the regulation of aerobic production of energy and is composed of 13 subunits. The 3 largest subunits (I, II, and III) forming the cataly...
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