Methods This pilot study is being conducted in two centers with a randomized, controlled study design using blinded and validated rater assessments and a sham procedure. The primary outcome variable is hand tremor and the Unified Parkinson’s disease rating scale in the medicated state at three months. Comprehensive cognitive assessments before and after the procedure are being conducted for add...

BACKGROUND There is a limited guidance for outcome reporting for cardiac arrest trials. This review was conducted to explore the degree of variation and identify trends in outcome reporting. METHODS Randomised controlled trials enrolling patients with cardiac arrest (2002-2012) were identified by applying a search strategy to four databases. Titles, abstracts and short-listed studies were ind...

Currently, when data are gathered from participants in clinical trials, these assessments typically take place in healthcare settings rather than in the context of patients’ daily lives. In addition, many assessments of physical function rely on relatively subjective outcome measures that are reported by participants or their healthcare providers. In addition to being limited in terms of their ...

The primary outcome measure is safety, including mortality and morbidity (intraoperative outcomes: operative duration, cross-clamp time, conversion rates; perioperative outcomes: myocardial infarction, atrial fibrillation, neurological adverse events, bleeding, transfusion, re-exploration, septic complications, pain, hospital stay, and discharge disposition). Secondary outcome measures include ...