Dynamin-related GTPase proteins (DRPs) are main players in membrane remodelling. Conserved DRPs called mitofusins (Mfn1/Mfn2/Fzo1) mediate the fusion of mitochondrial outer membranes (OM). OM fusion depends on self-assembly and GTPase activity of mitofusins as well as on two other proteins, Ugo1 and Mdm30. Here, we define distinct steps of the OM fusion cycle using in vitro and in vivo approach...

The Bcl-2 family proteins Bax and Bak are essential for the execution of many apoptotic programs. During apoptosis, Bax translocates to the mitochondria and mediates the permeabilization of the outer membrane, thereby facilitating the release of pro-apoptotic proteins. Yet the mechanistic details of the Bax-induced membrane permeabilization have so far remained elusive. Here, we demonstrate tha...

purpose : to determine the optical coherence tomography (oct) findings in eyes with idiopathic perifoveal retinal telangiectasis (ipt) methods : this study is a retrospective review of patient charts, oct, fundus photography, related to 16 eyes (11 patients). results : the most consistent finding of idiopathic perifoveal telangiectasia seen in 93.7% of eyes (15 eyes) on oct was the presence of ...

a theoretical solution is presented for the forced convection heat transfer of a viscoelastic fluid obeying the giesekus constitutive equation in a concentric annulus under steady state, laminar, and purely tangential flow. a relative rotational motion exists between the inner and the outer cylinders, which induces the flow. a constant temperature was set in both cylinders, in this study. the f...

Endocarp morphology of 4 species of Iranian Celtis was examined using light and scanning electron microscopes. Macro- and micro-morphological characters were included endocarp shape, color, size, surrounding rim, ornamentation and SEM structure of the outer layer of the endocarp. Endocarp morphology of the examined specimens exhibit variation in all characters. Endocarp shape varies from globul...