1. Materials: .................................................................................................................... 2 2. Structure of PAMAM dendrimers: ............................................................................. 2 3. Instrumentation: .......................................................................................................... 2 4. Experimental condi...

Background: Lung cancer is a disease of the respiratory system that gets special attention because World Health Organization (WHO) has reported in 2018, lung was with highest number morbidity and mortality rate world. There are several types cancer, one which adenocarcinoma, accounts for about 40% all cancers. In its management, cells often develop resistance to EGFR TKI drugs while Cisplatin C...

Specific and robust targeting of pathogenic cells would represent a major advance in treatment eye diseases including diabetic retinopathy. In article number 2000181 Rangaramanujam M. Kannan, Elia J. Duh co-workers use the corticosteroid triamcinolone conjugated to surface PAMAM-dendrimers, which are tree-like branching polymeric nanoparticles. This dendrimer-triamcinolone conjugate selectively...

We report the synthesis, characterization, and extraction of Au dendrimer-encapsulated nanoparticles (DENs) prepared in organic solvents. DENs composed of 31 and 55 Au atoms were prepared using organic solvents and poly(amidoamine) (PAMAM) dendrimer templates modified on their periphery with dodecyl groups. The spectral and microscopic properties of the resulting materials were identical to tho...

The use of data mining techniques in the field of nanomedicine has been very limited. In this paper we demonstrate that data mining techniques can be used for the development of predictive models of the cytotoxicity of poly(amido amine) (PAMAM) dendrimers using their chemical and structural properties. We present predictive models developed using 103 PAMAM dendrimer cytotoxicity values that wer...

We report various structural and conformational properties of generations 4, 5, and 6 PAMAM (polyamidoamine) dendrimer [EDA (ethylenediamine) core)] at various protonation levels through extensive molecular dynamics (MD) simulations in explicit solvent. The presence of solvent leads to swelling of the dendrimer (by 33% for G5 compared to the case of no solvent). We find that decreasing the solu...

Commercial generation-five poly(amidoamine) dendrimer material (G5c) was fractionated into its major structural components. Monomeric G5 (G5m; 21--30 kDa) was isolated to compare its functional properties to the G5c material. Diffusion-ordered nuclear magnetic resonance spectroscopy was employed to measure the self-diffusion coefficients and corresponding hydrodynamic radii of G5m and other G5c...

In this contribution, we report the successful preparation of supported metal catalysts using dendrimer-encapsulated Pt nanoparticles as metal precursors. Polyamidoamine (PAMAM) dendrimers were first used to template and stabilize Pt nanoparticles prepared in solution. These dendrimer-encapsulated nanoparticles were then deposited onto a commercial high surface area silica support and thermally...

Oral delivery remains a challenge for poorly permeable hydrophilic macromolecules. Poly(amido amine) (PAMAM) dendrimers have shown potential for their possible oral delivery. Transepithelial transport of carboxyl-terminated G3.5 and amine-terminated G4 PAMAM dendrimers was assessed using isolated rat jejunal mucosae mounted in Ussing chambers. The 1 mM FITC-labeled dendrimers were added to the ...