نتایج جستجو برای: pamam dendrimer

تعداد نتایج: 2681  

Journal: :Bioconjugate chemistry 2007
Xue-Qing Zhang Janjira Intra Aliasger K Salem

We report on the preparation and characterization of poly(D, L-lactide-co-glycolide) (PLGA) microparticles with surface-conjugated polyamidoamine (PAMAM) dendrimers of varying generations. The buffering capacity and zeta-potential of the PLGA PAMAM microparticles increased with increasing generation level of the PAMAM dendrimer conjugated. Conjugation of the PAMAM dendrimer to the surface of th...

Journal: :Colloids and surfaces. B, Biointerfaces 2015
Prashant Kesharwani Lingxiao Xie Sanjeev Banerjee Guangzhao Mao Subhash Padhye Fazlul H Sarkar Arun K Iyer

The current study was aimed to develop a targeted dendrimer formulation of 3, 4-difluorobenzylidene curcumin (CDF) and evaluate its potential in CD44 targeted therapy for pancreatic cancer. Using amine terminated fourth generation poly(amidoamine) (PAMAM) dendrimer nanocarrier and hyaluronic acid (HA) as a targeting ligand, we engineered a CD44-targeted PAMAM dendrimer (HA-PAMAM) formulation of...

2015
Łukasz Uram Magdalena Szuster Aleksandra Filipowicz Krzysztof Gargasz Stanisław Wołowiec Elżbieta Wałajtys-Rode

The intracellular localization and colocalization of a fluorescently labeled G3 amine-terminated cationic polyamidoamine (PAMAM) dendrimer and its biotin-pyridoxal (BC-PAMAM) bioconjugate were investigated in a concentration-dependent manner in normal human fibroblast (BJ) and squamous epithelial carcinoma (SCC-15) cell lines. After 24 hours treatment, both cell lines revealed different pattern...

2013
Fei Wang Naimin Shao Yiyun Cheng

In this study, the host-guest behavior of poly(amidoamine) (PAMAM) dendrimers bearing amine, hydroxyl, or carboxylate surface functionalities were investigated by paramagnetic NMR studies. 2,2,6,6-Tetramethylpiperidinyloxy (TEMPO) derivatives were used as paramagnetic guest molecules. The results showed that TEMPO-COOH significantly broaden the ¹H NMR peaks of amine- and hydroxyl-terminated PAM...

2011
Naimin Shao Yunzhang Su Jingjing Hu Jiahai Zhang Hongfeng Zhang Yiyun Cheng

BACKGROUND Polyamidoamine (PAMAM) and polypropylenimine (PPI) dendrimers are the commercially available and most widely used dendrimers in pharmaceutical sciences and biomedical engineering. In the present study, the loading and release behaviors of generation 3 PAMAM and generation 4 PPI dendrimers with the same amount of surface amine groups (32 per dendrimer) were compared using phenylbutazo...

Journal: :Biological & pharmaceutical bulletin 2010
Wen-Jun Yao Kao-Xiang Sun Yi Liu Na Liang Hong-Jie Mu Chen Yao Rong-Cai Liang Ai-Ping Wang

The aim of this study was to investigate the effect of Poly(amidoamine) (PAMAM) dendrimers on corneal permeation of puerarin (PUE). Permeation studies were performed using excised cornea of rabbits by a Valia-Chien diffusion apparatus. Drug-treatment studies were carried out by measuring the penetration of puerarin on cornea in PAMAM-PUE physical mixture or PAMAM-PUE complex, and cornea-treatme...

Journal: :Sensors & diagnostics 2023

Construction of poly(amidoamine) (PAMAM) dendrimer-based nanoplatforms for tumor computed tomography (CT) imaging and theranostics has gained significant attention in recent years. The unique characteristics PAMAM dendrimers such as monodispersity,...

Journal: :The Analyst 2006
Xiangyang Shi István J Majoros Anil K Patri Xiangdong Bi Mohammad T Islam Ankur Desai T Rose Ganser James R Baker

Poly(amidoamine) (PAMAM) dendrimer-based nanodevices are of recent interest in targeted cancer therapy. Characterization of mono- and multifunctional PAMAM-based nanodevices remains a great challenge because of their molecular complexity. In this work, various mono- and multifunctional nanodevices based on PAMAM G5 (generation 5) dendrimer were characterized by UV-Vis spectrometry, (1)H NMR, si...

2016
Natalia Oddone Nicole Lecot Marcelo Fernández Alejandra Rodriguez-Haralambides Pablo Cabral Hugo Cerecetto Juan Claudio Benech

BACKGROUND Breast cancer is the second leading cause of cancer death worldwide. Nanotechnology approaches can overcome the side effects of chemotherapy as well as improve the efficacy of drugs. Dendrimers are nanometric size polymers which are suitable as drug delivery systems. To the best of our knowledge, studies on the application of PAMAM G4.5 (polyamidoamine half generation 4) dendrimers a...

2017
Yoonhee Bae Su Jeong Song Ji Young Mun Kyung Soo Ko Jin Han Joon Sig Choi Ravin Narain

The use of tumor-specific therapeutic agents is a promising option for efficient and safe nonviral gene transfer in gene therapy. In this study, we describe the efficacy of polyamidoamine (PAMAM)-based nonviral gene delivery carriers, namely, an ornithine conjugated PAMAM (PAMAM-O) dendrimer in delivering apoptin, a tumor-specific killer gene, into human hepatocellular carcinoma (HepG2 cells) a...

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