In the ongoing search for ever-brighter surface-enhanced Raman scattering (SERS) nanoprobes, gold nanostars (AuNSs) have emerged as one of the best geometries for producing SERS in a nonaggregated state. Despite their high enhancement factor, optical extinction from plasmon-matched nanoparticles can greatly attenuate the overall SERS intensity. Herein, we report the development of a new hybrid ...

From regular monitoring of the Double Quasar QSO 0957+561 A,B there is now general agreement on a time delay of about 416 days. This has made it possible to determine the microlensing residual in the light-curve, see Pelt et al. (1998). We have used two significant microlensing features: 1) A " quiet " period with a variability less than 0.05 mag lasting about 8 years, and 2) A change in the re...

This paper presents a new assay to determine the activity of the lysosomal enzyme α-N-acetylgalactosaminidase (Naga, EC 3.2.1.49) in human serum. It is based on the use of a new chromogenic substrate, DNP-α-GalNAc (2,4-dinitrophenyl-N-acetyl-α-D-galactosaminide) and is performed at pH 4.3 and 37 °C. This allows continuous monitoring of the absorbance of the released DNP. The assay can be perfor...

Horses are unusual in producing protein-rich sweat for thermoregulation, a major component of which is latherin, a highly surface-active, non-glycosylated protein. The amino acid sequence of latherin, determined from cDNA analysis, is highly conserved across four geographically dispersed equid species (horse, zebra, onager, ass), and is similar to a family of proteins only found previously in t...

Symptomatic and immunologic responses to allergens from laboratory mice were studied in a research institute. Subjects who had been exposed to mice and 50 unexposed subjects were studied by questionnaire and by prick tests with seven prevalent aeroallergens and allergens from mouse urine and pelts. Of the 121 exposed subjects, 39 (32.2%) had respiratory, ocular, or cutaneous symptoms after expo...

UNLABELLED ChIP-based technology is becoming the leading technology to globally profile thousands of transcription factors and elucidate the transcriptional regulation mechanisms in living cells. It has evolved rapidly in recent years, from hybridization with spotted or tiling microarray (ChIP-chip), to pair-end tag sequencing (ChIP-PET), to current massively parallel sequencing (ChIP-seq). Alt...

From regular monitoring of the Double Quasar QSO 0957+561 A,B there is now general agreement on a time delay of about 416 days. This has made it possible to determine the microlensing residual in the light-curve, see Pelt et al. (1998). We have used two significant microlensing features: 1) A " quiet " period with a variability less than 0.05 mag lasting about 8 years, and 2) A change in the re...

BACKGROUND Emergency cricothyroidotomy is a potentially life-saving procedure in the 'cannot intubate cannot ventilate (CICV)' scenario. Although surgical cricothyroidotomy remains the technique recommended in many 'CICV' algorithms, the insertion of a tracheostomy as a cannula over a trocar, or using the Seldinger method, may have advantages as they are more familiar to the anaesthetist. We co...