.........................................................................................................................................................8 INTRODUCTION............................................................................................................................................10 REVIEW OF THE LITERATURE .................................................................

The Human Genome Project has resulted in a new era in the field of pharmacogenetics in which researchers are rapidly discovering new genetic variation, which may help to explain interindividual variability in drug efficacy and toxicity. Pharmacogenetics is the study of the role of genetic inheritance in individual variation in drug response and toxicity. With the convergence of advances in phar...

Furthermore, Dr. Moulder is able to make the reader realize that the problem has considerable theoretical and practical value and is not just an exercise in semantics. It is a stimulating book. Investigators in a wide variety of fields will find this short volume an extremely useful reference book. The purpose of the monograph was to bring together the known biochemical and structural inherited...

Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical variation seen in response to pharmacotherapeutic drugs. This affects the likelihood of experiencing adverse drug reactions and also of achieving therapeutic success. In this paper, ...

Prediction models are the key to individualized drug therapy. Warfarin is a typical example of where pharmacogenetics could help the individual patient by modeling the dose, based on clinical factors and genetic variation in CYP2C9 and VKORC1. Clinical studies aiming to show whether pharmacogenetic warfarin dose predictions are superior to conventional initiation of warfarin are now underway. T...