BACKGROUND Pharmacogenetics has a potential for optimizing drug response and identifying risk of toxicity for patients. Pharmacogenetics knowledge of healthcare professionals and the unmet need for pharmacogenetics education in health training institutions are some of the challenges of integrating pharmacogenetics into routine medical practice. AIM To assess pharmacogenetics knowledge among h...

OBJECTIVE This study aimed to explore how well Victorian pharmacists perceived they understood pharmacogenetics, their perceived capacity to counsel a patient about such testing, how they believed pharmacogenetics would impact upon their profession, and to investigate the ways in which Victorian pharmacists would like to be educated about pharmacogenetics. METHODS A cross-sectional survey was...

pancreatic cancer (pc) is a progressive, fatal disease with a high degree of malignancy. more than 40000 peoplediefrom this cancer annually in the united states. as a multifactorial condition, pc has a complex nature, and there are several genes and signalingpathwaysimplicated in pc pathogenesis and progression. there are diffèrent mutations in master genesincludingtumorsuppressors and oncogene...

OBJECTIVES To review the fundamental concepts of pharmacogenetics and analyse how the broad principles of this rapidly emerging field may influence the treatment of rheumatic disease in future. METHODS The names of common rheumatic drugs and the terms 'pharmacogenetics', 'pharmacogenomics' and 'genetic polymorphism' were used as keywords to search the Medline and Current Contents databases. G...

Pharmacogenetics is the search for heritable genetic polymorphisms that influence responses to drug therapy. The most important application of pharmacogenetics is to guide choosing agents with the greatest potential of efficacy and smallest risk of adverse drug reactions. Many studies focussing on drug-gene interactions have been published in recent years, some of which led to adaptation of FDA...

BACKGROUND Pharmacogenetics is an emerging field currently being implemented to improve safety when prescribing drugs. While many women who take drugs during pregnancy would likely benefit from such personalized drug therapy, data is lacking on the awareness towards pharmacogenetics among women. We aim to determine the level of knowledge and acceptance of formerly pregnant women in the Netherla...

In September this year the Nuffield Council on Bioethics held a meeting to disclose and discuss the main findings of their newly published report on the ethical issues associated with developments in pharmacogenetics research. The basics of pharmacogenetics science is briefly outlined, and then the extent to which the report was successful in addressing (or at least highlighting) the attendant ...

Abstract Background Risk assessment models are at the core of flight medicine, weighing both impact environment on an aviator and potential medical events in aviators operations. Pharmacogenetics is application a patient’s genetic information to reduce medication risk. Here, we use three conditions commonly encountered by U.S. Air Force’s medicine community (asthma, diabetes, hypertension) demo...

Design: The authors built and evaluated several candidate statistical models that characterize pharmacogenetics articles in terms of word usage and the profile of Medical Subject Headings (MeSH) used in those articles. The bestperforming model was used to scan the entire Medline article database (11 million articles) to identify candidate pharmacogenetics articles. Results: A sampling of the ar...