OBJECTIVE To conduct a meta-analysis on randomized, controlled treatment trials of pediatric obsessive-compulsive disorder (OCD). METHOD Studies were included if they employed randomized, controlled methodology and treated young people (19 years or under) with OCD. A comprehensive literature search identified 13 RCTs containing 10 pharmacotherapy to control comparisons (N = 1016) and five cog...

traditionally, schizophrenia was considered to be a severe psychiatric disorder, with a chronic course and an unfavorable outcome. throughout history, there has been incidence of schizophrenia, roughly one percent of the population, consistently, in every culture. it is generally acknowledged that schizophrenia has multifactorial etiology, with multiple susceptibility genes interacting with env...

BACKGROUND Few clinical trials have evaluated interventions for major depressive disorder in samples of low-income minority women, and little is known about the cost-effectiveness of depression interventions for this population. OBJECTIVE To evaluate the cost-effectiveness of pharmacotherapy or cognitive behavior therapy (CBT) compared with community referral for major depression in low-incom...

There is currently no pharmacotherapy for obstructive sleep apnoea (OSA) but there is no principled a priori reason why there should not be one. This review identifies a rational decision-making strategy with the necessary logical underpinnings that any reasonable approach would be expected to navigate to develop a viable pharmacotherapy for OSA. The process first involves phenotyping an indivi...

Introduction: Chronic prostatitis is an obtrusive, annoying and common disease that many people are suffering from it, and it is followed by complicated problems for the patient and the treating physician because of recrudescence of the disease. Materials and Methods: In this interventional study 20 patients with prostatitis, who had no satisfactory answer to the common pharmacotherapy, were s...

With its medicalization as a brain-based disease, addiction has come to be regarded as amenable to biomedical treatment approaches, most commonly pharmacotherapy. Various vulnerabilities are recognized to contribute to maladaptive substance use, and have been linked to diverse neurobiological alterations that may be targeted with pharmacotherapy: withdrawal, craving and cue reactivity, and aber...

Modern society expects pharmacists to be more involved in monitoring and supervising pharmacotherapy. International documents clearly define pharmacists as guardians of the safety and effectiveness of pharmacotherapy, not coincidentally putting safety matters first. With regard to this issue, the National Section of Pharmaceutical Care of the Polish Pharmaceutical Society hereby presents its ow...

Pharmacotherapy has made massive advances: what began with herbs and fungi led to synthetic pills that interfered ever more precisely receptors metabolic pathways. Finally, antibodies against specific proteins became part of our therapeutic armamentarium. But none these measures get the heart matter: latest revolutionary chapter in pharmacotherapy uses organ-specific nucleotides, short RNA sequ...