We aimed to test the feasibility of quantifying insulin action on cellular K(+) uptake in vivo in the conscious rat by measuring the exogenous K(+) infusion rate needed to maintain constant plasma K(+) concentration ([K(+)]) during insulin infusion. In this "K(+) clamp" the K(+) infusion rate required to clamp plasma [K(+)] is a measure of insulin action to increase net plasma K(+) disappearanc...

Background: There is not any in vivo studies that shows inducing of euglycemia by vanadyl is independent from plasma insulin.  Therefore in the present study we planned to investigate the antidiabetic effects of vanadyl in diabetic rats. Materials and Methods: Rats became severely diabetic by an IV injection of 50-55mg/kg streptozotocin (STZ), 15 days after the injection, the blood glucose of ...

leptin affects paraventricular nucleus of hypothalamus and reduces appetite while activation of α2-adrenoceptors at this site has opposite action. the reducing effect of α2-adrenoceptors inhibition on body weight and appetite and also enhancing effects on lipolysis, sympathetic activation and plasma insulin levels in animals have been reported. we studied the effect of yohimbine treatment (2 mg...

the purpose of the present study was to investigate the effect of endurance (et), resistance (rt) and concurrent training (ct) on plasma levels of visfatin, insulin, glucose and insulin resistance of non-athlete men with obesity. it was a semi-experimental study. thirty six men [age: 21.48 (0.25), and bf%: 27.39 (0.52)], voluntarily participated in this study after public announcement in univer...

To determine the dose-response characteristics for the effects of insulin on glucose production, glucose utilization, and overall glucose metabolism in normal man, 15 healthy subjects were infused with insulin for 8 h at sequential rates ranging from 0.2 to 5.0 mU.kg-1.min-1; each rate was used for 2 h. Glucose production and utilization were measured isotopically ([3-3H]glucose). Tissue insuli...

objective(s):some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. incidence of these condition increases with aging. on the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (nos) activity is also altered in diabetes. in this study, modification in the enzyme activity associated with aging a...

of delivery (14) the mean (±SE) plasma concentration of glucose was 99±7 mg/100 ml, insulin 32±6 ,uU/ml, glucagon 183±17 pg/ml. These levels were similar to those occurring in mothers who did not have an i.v. infusion, permitting pooling of the two groups for further analysis. The 't' test for paired data was used for statistical comparison of plasma concentrations of metabolite or hormones. Th...