The recent article by Rubio et al. reports poor accuracy of rapid malaria diagnostic tests (RDTs) and promotes PCRbased reference laboratories to avoid potential misdiagnosis (6). Both points deserve comment. The authors’ reported low sensitivity is mainly due to poor detection of Plasmodium species other than Plasmodium falciparum. Although “pan-specific” antibodies have been included in some ...

some dorema species are used in persian traditional medicine. in the present study the total extract from the roots of dorema hyrcanum koso-pol. was investigated for its in vitro (pldh assay) and in vivo (peters’ 4-days suppressive test) antiplasmodial effects and assessed for cytotoxicity against the normal cell line mdbk (mtt test). the ic50 values for a chloroquine- sensitive (3d7) and a chl...

The recent article by Rubio et al. reports poor accuracy of rapid malaria diagnostic tests (RDTs) and promotes PCRbased reference laboratories to avoid potential misdiagnosis (6). Both points deserve comment. The authors’ reported low sensitivity is mainly due to poor detection of Plasmodium species other than Plasmodium falciparum. Although “pan-specific” antibodies have been included in some ...

We report here a dual-ELISA method to measure Malaria biomarkers concurrently in the same aliquot of blood sample. A correlation between parasite numbers and ELISA values determined figures were used establish standard graph. Thick smears prepared from spiked samples also Giemsa stained density by microscopy (It was thereby possible undertake an objective comparison lactate dehydrogenase histid...

Some Dorema species are used in Persian traditional medicine. In the present study the total extract from the roots of Dorema hyrcanum Koso-Pol. was investigated for its in vitro (pLDH assay) and in vivo (Peters’ 4-days suppressive test) antiplasmodial effects and assessed for cytotoxicity against the normal cell line MDBK (MTT test). The IC50 values for a chloroquine- sensitive (3D7) and a chl...

BACKGROUND Human population movement across country borders presents a real challenge for malaria control and elimination efforts in Cambodia and its neighbouring countries. To quantify Plasmodium infection among the border-crossing population, including asymptomatic and artemisinin resistant (AR) parasites, three official border crossing points, one from each of Cambodia's borders with Thailan...

BACKGROUND Eradication of malaria will depend on discovery of new intervention tools such as anti-malarial drugs. Due to the increasing interest in the application of propolis against significant clinical pathogenic agents, the aim of the present investigation was to evaluate the anti-plasmodial effect of Iranian propolis extracts against chloroquine (CQ)-sensitive Plasmodium falciparum 3D7 and...