نتایج جستجو برای: pldh

تعداد نتایج: 124  

Journal: :Health technology assessment 2011
D Papaioannou R Rafia M D Stevenson J W Stevens P Evans

The paper presents a summary of the evidence review group (ERG) report into the clinical effectiveness and cost-effectiveness of trabectedin for the treatment of relapsed platinum-sensitive ovarian cancer, based upon a review of the manufacturer's submission to the National Institute for Health and Clinical Excellence (NICE) as part of the single technology appraisal process. The submission add...

Journal: :Health technology assessment 2015
Steven J Edwards Samantha Barton Elizabeth Thurgar Nicola Trevor

BACKGROUND Ovarian cancer is the fifth most common cancer in the UK, and the fourth most common cause of cancer death. Of those people successfully treated with first-line chemotherapy, 55-75% will relapse within 2 years. At this time, it is uncertain which chemotherapy regimen is more clinically effective and cost-effective for the treatment of recurrent, advanced ovarian cancer. OBJECTIVES ...

2013
Muhamad Ali Tetrawindu A Hidayatullah Zulfikar Alimuddin Yunita Sabrina

BACKGROUND pfmdr1 and its variants are molecular marker which are responsible for antibiotics resistance in Plasmodium falciparum, a parasitic carrier for malaria disease. A novel strategy to treat malaria disease is by disrupting parasite lactate dehydrogenase (pLDH), a crucial enzyme for Plasmodium survival during their erythrocytic stages. This research was aimed to investigate and character...

2014
Mina Yan Zhaoguo Zhang Shengmiao Cui Ming Lei Ke Zeng Yunhui Liao Weijing Chu Yihui Deng Chunshun Zhao

Layered double hydroxide (LDH) has attracted considerable attention as a drug carrier. However, because of its poor in vivo behavior, polyethylene glycolylated (PEGylated) phospholipid must be used as a coformer to produce self-assembled core-shell nanoparticles. In the present study, we prepared a PEGylated phospholipid-coated LDH (PLDH) (PEG-PLDH) delivery system. The PEG-PLDH nanoparticles h...

Journal: :Transactions of the Royal Society of Tropical Medicine and Hygiene 2008
Carole Fogg Rogers Twesigye Vincent Batwala Patrice Piola Carolyn Nabasumba James Kiguli Frederick Mutebi Christa Hook Martine Guillerm Anthony Moody Jean-Paul Guthmann

A study to assess the diagnostic capabilities of three parasite lactate dehydrogenase (pan-pLDH) tests, Vistapan), Carestart and Parabank), was conducted in Uganda. An HRP2 test, Paracheck-Pf), and a Giemsa-stained blood film were performed with the pLDH tests for outpatients with suspected malaria. In total, 460 subjects were recruited: 248 with positive blood films and 212 with negative blood...

Journal: :Materials Letters 2021

Porous few-layer NiFe-layered double hydroxide (PLDH)/graphene oxide (GO) composite electrocatalysts (PLDH/GO) were successfully synthesized through a formamide-assisted coprecipitation method. The ratio of PLDH to GO was optimized, and the structure, morphology electrochemical properties samples systematically investigated. results show that with obvious porous features uniformly grows on GO, ...

Journal: :Journal of clinical microbiology 2017
Moses Murungi Travis Fulton Raquel Reyes Michael Matte Moses Ntaro Edgar Mulogo Dan Nyehangane Jonathan J Juliano Mark J Siedner Yap Boum Ross M Boyce

Poor specificity may negatively impact rapid diagnostic test (RDT)-based diagnostic strategies for malaria. We performed real-time PCR on a subset of subjects who had undergone diagnostic testing with a multiple-antigen (histidine-rich protein 2 and pan-lactate dehydrogenase pLDH [HRP2/pLDH]) RDT and microscopy. We determined the sensitivity and specificity of the RDT in comparison to results o...

Journal: :iranian journal of parasitology 0
muhamad ali laboratory of microbiology and biotechnology, faculty of animal sciences, mataram university, mataram, indonesia. tetrawindu a hidayatullah laboratory of microbiology faculty of medical, mataram university, mataram, indonesia. zulfikar alimuddin faculty of animal science, nahdathul wathan university, mataram, indonesia. yunita sabrina laboratory of microbiology faculty of medical, mataram university, mataram, indonesia.

background: pfmdr1 and its variants are molecular marker which are responsible for antibiotics resistance in plasmodium falciparum, a parasitic carrier for malaria dis-ease. a novel strategy to treat malaria disease is by disrupting parasite lactate dehy-drogenase (pldh), a crucial enzyme for plasmodium survival during their erythro-cytic stages. this research was aimed to investigate and chara...

Journal: :The Journal of antimicrobial chemotherapy 2013
Sarah D'Alessandro Francesco Silvestrini Koen Dechering Yolanda Corbett Silvia Parapini Martijn Timmerman Laura Galastri Nicoletta Basilico Robert Sauerwein Pietro Alano Donatella Taramelli

OBJECTIVES Plasmodium gametocytes, responsible for malaria parasite transmission from humans to mosquitoes, represent a crucial target for new antimalarial drugs to achieve malaria elimination/eradication. We developed a novel colorimetric screening method for anti-gametocyte compounds based on the parasite lactate dehydrogenase (pLDH) assay, already standardized for asexual stages, to measure ...

Journal: :Health technology assessment 2006
C Main L Bojke S Griffin G Norman M Barbieri L Mather D Stark S Palmer R Riemsma

OBJECTIVES To examine the clinical effectiveness and cost-effectiveness of intravenous formulations of topotecan monotherapy, pegylated liposomal doxorubicin hydorocholoride (PLDH) monotherapy and paclitaxel used alone or in combination with a platinum-based compound for the second-line or subsequent treatment of advanced ovarian cancer. DATA SOURCES Electronic databases covering publication ...

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