BACKGROUND There is an urgent need for alternative rescue therapies in invasive infections caused by methicillin-resistant Staphylococcus aureus (MRSA). We assessed the clinical efficacy and safety of the combination of fosfomycin and imipenem as rescue therapy for MRSA infective endocarditis and complicated bacteremia. METHODS The trial was conducted between 2001 and 2010 in 3 Spanish hospit...

Patients with inflammatory bowel disease (IBD) are a high risk population for bacteremia. Derangement in the mucosal architecture of the gastrointestinal (GI) tract and frequent endoscopic interventions in immunocompromised individuals are considered primary causes. Isolation of opportunistic microorganisms from the bloodstream of IBD patients has been increasingly reported in recent years. Lec...

Pseudomonas aeruginosa is an opportunistic pathogen that causes frequently nosocomial infections, currently becoming more difficult to treat due to the various resistance mechanisms and different virulence factors. The purpose of this study was to determine the risk factors independently associated with the development of bacteremia by carbapenem-resistant P. aeruginosa, the frequency of virule...

BACKGROUND Tigecycline is effective in the treatment of complicated skin/skin-structure infection (cSSSI), complicated intraabdominal infection (cIAI), and community-acquired bacterial pneumonia (CAP), but its efficacy in subjects with secondary bacteremia is unknown. METHODS Pooled data from subjects enrolled for treatment of cSSSI, cIAI, or CAP presenting with bacteremia from 7 double-blind...

BACKGROUND AND PURPOSE Group B streptococcus (GBS) [Streptococcus agalactiae] is an emerging cause of disease in non-pregnant adults with underlying diseases. This retrospective study analyzed 90 episodes of GBS bacteremia in adults occurring over a 4-year period. METHODS Basic and clinical data were collected by reviewing medical charts of patients. Blood cultures were performed on admission...

Nontyphoid salmonellae are major causes of foodborne infection worldwide. They still seriously affect human health, causing morbidity and mortality. They induce severe salmonellosis, even in modestly immunocompromised hosts, resulting in bacteremic spread, focal infection, and persistence in deep sites, including the en-dovascular region. Approximately 5% of individuals with gastrointestinal il...

introduction sphingobacterium multivorum is a gram-negative, nonfermentative bacillus that rarely causes disease in humans. in the medical literature, only a few cases of infections caused by this organism have been reported. almost all the reported cases of this infection were associated with conditions that decrease immunity. case presentation to the best of our knowledge, we are reporting th...

The frequency of, risk factors for, and outcome of polyclonal gram-negative bacteremia are still unknown. We investigated them in a prospective cohort study of patients for whom a blood culture yielded >/=1 species of gram-negative aerobic rod. For each patient, pulsed field gel electrophoresis (PFGE) was performed on 4 colonies of each morphologic type. Episodes of bacteremia were considered p...

the south eastern region of iran is an endemic area for salmonellosis. sometimes bacteremia due to nontyphoidal salmonella occurs but certain patients are at increased risk for recurrent bacteremia. the risk of invasive salmonellosis and recurrent bacteremia is increased in the patients with immunosuppression, especially impaired cell-mediated immunity, lymphoproliferative diseases and in patie...