The distribution of antibody-forming cells of different specificities in the lymph nodes and spleens of guinea pigs immunized with two separate antigens or with antigens bearing two determinants was studied. When animals were immunized with two soluble protein antigens or antigens in which the two antigenic determinants were on the same molecule, antibody-forming cells of different specificitie...

the influenza a virus is of global concern for the poultry industry, especially the h5 subtype as it has the potential to become highly pathogenic for poultry and mankind. recently, plant expression systems have gained interest as an alternative for the production of vaccine antigens. the goal of the present study was to investigate the possibility of expressing the ha1 protein in nicotiana tab...

Abstract T cell large granular lymphocyte leukemia (T-LGLL) is characterized by clonal expansion of cytotoxic cells and neutropenia. Compared to 1% the general population, about 25% T-LGLL patients develop rheumatoid arthritis (RA), an autoimmune disease anti-citrullinated protein antibodies (ACPAs). To investigate response in with both RA (T-LGLL/RA), we analyzed their ACPA positivity specific...

Brucellosis is a well-known infection in domestic animals which caused by Brucella bacterium. Due toserious economic and medical consequences of this disease, various efforts have been made to prevent theinfection through the use of recombinant vaccines based on Brucella outer membrane protein (OMP)antigens. The objectives of the present study were cloning, sequencing and epitope prediction of ...

background: toxocariasis is a prevalent zoonosis disease caused by the closely related nematode species toxocara canis and toxocara cati which parasitise canidae and felidae respectively. in paratenic hosts, larvae of these worms cause multiple organ damage. however, how these paratenic hosts response to these worms and whether any common biomarker can be applied for diagnosis are still unclear...

MOTIVATION Discovery of novel protective antigens is fundamental to the development of vaccines for existing and emerging pathogens. Most computational methods for predicting protein antigenicity rely directly on homology with previously characterized protective antigens; however, homology-based methods will fail to discover truly novel protective antigens. Thus, there is a significant need for...

Most natural and synthetic antibodies are ‘unseen’. That is, the demonstration of their neutralization effects with any antigen requires laborious costly wet-lab experiments. The existing methods that learn antibody representations from known antibody–antigen interactions unsuitable for unseen owing to absence interaction instances. DeepAAI method proposed herein learns by constructing two adap...

In vitro diagnostic kits use immune chromatographic assay with gold nanoparticle conjugated antigen / antibody coated in the kit that specifically detects of pathogen or to a blood serum tested. Such are available for wide variety diseases and different could antigens targeted. this research article I present novel finding when latex Calotropis gigantea Thevetia peruviana is used as sample targ...

BACKGROUND Immunoglobulin G antibodies (Abs) to Plasmodium falciparum antigens have been associated with naturally acquired immunity to symptomatic malaria. METHODS We probed protein microarrays covering 824 unique P. falciparum protein features with plasma from residents of a community in Kenya monitored for 12 weeks for (re)infection and symptomatic malaria after administration of antimalar...