OBJECTIVES In phase II clinical trials in oncology, the potential efficacy of a new treatment regimen is assessed in terms of anticancer activity. The standard approach consists of a single-arm two-stage design where a single binary endpoint is compared to a specified target value. However, a new drug would still be considered promising if it showed a lower tumor response rate than the target l...

Present medical practice encourages management according to written guidelines, protocols, and structured procedures (GPPs). Daily medical practice includes instances in which "leaping" from one patient management routine to another is a must. We define "frozen patient management", when patient management leaping was required but was not performed. Frozen patient management may cause significan...

The objective of the present study was to analyse the effects of implant supported overdentures on masticatory function in patients with an extremely resorbed mandible, and to compare the masticatory function in these patients using three differing types of implant treatment protocols. The mandibular overdentures were retained by a transmandibular implant, by four endosseous implants following ...

Within the semibosonized SU(3)-NJL model the mass splittings of baryons and the axial vector coupling constants of the nucleon are evaluated. The mass splittings of the hyperons are reproduced with great accuracy if second order corrections in ms are taken into account. email:[email protected] email:[email protected] email:[email protected]

This paper investigates the combination of expert critiquing systems and formal medical protocols. Medical protocols might serve as a suitable basis for an expert critiquing system because of the ongoing acceptance of medical protocols and the rise of both evidence-based practice and evidence-based protocols. A prerequisite for a critiquing system based on medical protocols is the ability to ma...

Protocols can be helpful in specific situations and may have show benefits in clinical trials. So-called evidence based protocols and checklists frequently remind clinicians to do the obvious, but may also contain as part of a bundle, elements that are not based on the best current evidence. However, so called quality improvement programs frequently call for implementation of the total bundle. ...

To my father who taught me that " M9ntıq elmlerin elmidir " and to my mother with the deepest gratitude...

address inclusive education and, increasingly, distance education is seen as a flexible and appropriately inclusive way to deliver such courses. In this article a team of colleagues, Kieron Sheehy, Jonathan Rix, Melanie Nind and Katy Simmons, discusses the development of an Open University course, E243 Inclusive Education: Learning from Each Other, which was launched in February 2004. The team ...

To my father who taught me that " M9ntıq elmlerin elmidir " and to my mother with the deepest gratitude...