PURPOSE To quantify the risk of radiation-induced second malignancies (SMN) in pediatric patients receiving craniospinal irradiation (CSI) either with 3-dimensional conformal radiation therapy (Conv CSI) or tomotherapy helical intensity modulated radiation therapy (Tomo CSI). METHODS AND MATERIALS A novel predictive model that accounts for short- and long-term carcinogenesis was incorporated ...

Radiotherapy (RT) is generally considered to be one of the most effective cancer treatments. The primary goal of RT is to accurately induce radiation damage to the tumor while limiting radiation toxicity to a level acceptable to normal tissue. This is accomplished by targeting the tumor with radiation. On the other hand, the status of RT procedures as they stand today is not substantial enough ...

Innovation/Impact: Robust real-time aperture adaptation for lung tumors during radiation therapy promises better local control while more healthy tissue can be spared. In this context we present the first implementation of a real-time adaptive therapy system using soft tissue localization (STiL) on continuously throughout the treatment acquired cine EPID images to maintain a dynamic treatment a...

Abstract Background: The Coronavirus disease 2019 (COVID-19) is spreading rapidly throughout the world. Lung primary organ which COVID-19 virus affects and leads to pneumonia, an acute respiratory distress syndrome. infects lower system, lung’s response this infection recruiting macrophages monocytes leading inflammation, causes widespread damage airways. Aim: purpose of study review studies us...

This project aimed to set up a Beagle dog model of radiation-induced lung injury in order to supply fresh lung tissue samples in the different injury phases for gene and protein research. Three dogs received 18 Gy X-ray irradiation in one fraction, another three dogs received 8 Gy in each of three fractions at weekly intervals, and one control dog was not irradiated. Acute pneumonitis was obser...

Background: Radiation Pneumonia (RP) is one of the most extensive side effects in Stereotactic Body Radiotherapy (SBRT) of lung cancer. SBRT are performed by means of Intensity Modulated Radiotherapy (IMRT), Intensity Modulated Arc Therapy (IMAT), CyberKnife (CK) or Helical Tomotherapy (HT) treatment methods. In this study, we performed a plan study to determine the plan parameter such as the M...

This article discusses the potential benefits and limitations of positron emission tomography (PET) for characterizing lung nodules, staging the mediastinum, identifying occult distant metastasis, determining prognosis and treatment response, guiding plans for radiation therapy, restaging during and after treatment, and selecting targets for tissue sampling. The key findings from the medical li...

This manuscript evaluates the role of cell killing, tissue disorganization, and tissue damage on the induction of lung cancer following low dose rate radiation exposures from internally deposited radioactive materials. Beagle dogs were exposed by inhalation to 90Y, 91Y, 144Ce, or 90Sr in fused clay particles. Dogs lived out their life span with complete pathology conducted at the time of death....

STUDY OBJECTIVES To determine whether acute changes in shielded lungs can be detected by positron emission tomography (PET) after radiation therapy. DESIGN Retrospective cohort study. SETTING University-affiliated medical center. PATIENTS Sixteen patients undergoing radiation therapy for lung cancer who had PET scans after receiving treatment. INTERVENTIONS None. MEASUREMENTS AND RESU...