PURPOSE Radiation therapy plays an essential role in the treatment of locally advanced lung cancer, but it inevitably leads to incidental and unnecessary dose to critical organs, including the lung, heart, and esophagus. Numerous radiation dose-volumetric parameters have been associated with increased risk of morbidity and mortality. The purpose of the present study is to quantify differences i...

Radiation-induced lung injury is one of the most prominent factors that interfere with chest cancer radiotherapy, and poses a great threat to patients exposed to total body irradiation. Upregulation of pro-oxidant enzymes is one of the main mechanisms through which the late effects of ionizing radiation on lung injury can be exerted. Interleukin (IL)-4 and IL-13 are two important cytokines that...

BACKGROUND Patients with solid malignant tumours are at increased risk of Pneumocystis jiroveci infection from immunosuppression as a result of chemotherapy and/or radiotherapy, but active Pneumocystis pneumonia (PCP) in untreated lung cancer is uncommon. CASE PRESENTATION A 43-year-old woman presented with prolonged fever, progressive dyspnoea, diffuse alveolar and interstitial infiltrates. ...

Though adjuvant radiotherapy has an established role in the treatment of carcinoma breast, there is concern regarding irradiation to heart and lung, more on left sided disease. Intensity Modulated Radiation Therapy (IMRT) modulates intensity radiation beams with better accuracy, sparing surrounding normal organs. But it increases integral dose healthy tissues compared 3-Dimensional Conformal (3...

Radiation pneumonitis is a well-characterized clinicopathological syndrome. The severity of radiation-induced lung injury correlates, among other factors, with the extent of lung volume incorporated within the field of radiation. The present article describes the cases of two patients with radiation pneumonitis following pneumonectomy and mediastinal radiotherapy. Postpneumonectomy pulmonary-me...

Most extensive-stage small cell lung cancers have disseminated disease at diagnosis, and solitary adrenal metastasis from small cell lung cancer is rare. We report the case of a 51-year-old man with extensive-stage small cell lung cancer with solitary right adrenal metastasis (T2N0M1), who was cured with resection of primary tumor, chemotherapy (cisplatin, etoposide), adrenalectomy, consolidati...

Background: Inflammatory myofibroblastic tumor (IMT) is a tumor composed of myofibroblasts and a mixed inflammatory infiltrate that rarely undergoes malignant transformation. The most common sites of involvement include the lung, liver and orbit, but it has been reported to occur in nearly every site of the body, including oral cavity and soft tissue. Although common in other sites, such a tumo...

Abstract Background : To explore the correlations of cofilin1 (CFL1) and phosphorylation level locus serine residue at position 3 (Ser3) with sensitivity elderly patients non-small cell lung cancer (NSCLC) to radiotherapy. Methods A total 102 eligible treated from June 2013 April 2015 were selected. The cases complete remission partial included into radiotherapy-sensitive group (n=55), while th...

As we know breast cancer is the second death reason in Iran. One step of treatment process is radiotherapy, which needs careful consideration of contouring and therapeutic techniques Lung, thyroid, spinal cord, trachea and humerus are sensitive organs in breast cancer radiation therapy.  The most clinical studies recommended two ways for delivering 95 percent of dose to supraclavicular and ...

INTRODUCTION/AIM Lung cancer is a leading cause of mortality among patients with carcinomas. The aim of this study was to point out risk factors for brain metastases (BM) appearance in patients with IIIA (N2) stage of nonsmall cell lung cancer (NSCLC) treated with three-modal therapy. METHODS We analyzed data obtained from 107 patients with IIIA (N2) stage of NSCLC treated surgically with neo...