The physiological role of mitochondrial uncoupling proteins (UCPs) in heart and skeletal muscle is unknown, as is whether mitochondrial uncoupling of oxidative phosphorylation by fatty acids occurs in vivo. In this study, we found that UCP2 and UCP3 protein content, determined using Western blotting, was increased by 32 and 48%, respectively, in hyperthyroid rat heart mitochondria. Oligomycin-i...

The stereoselectivity in the reduction of 4-benzoylpyridine (4-BP) was examined in the cytosolic fractions from the heart of 9 vertebrates (pig, rabbit, guinea pig, rat, mouse, chicken, soft-shelled turtle, frog and flounder). 4-BP was stereoselectively reduced to S(-)-alpha-phenyl-4-pyridylmethanol [S(-)-PPOL] in the cytosolic fractions from the heart of pig, rabbit and guinea pig. However, of...

Abstract Melissa officinalis has antioxidant and anti-inflammatory activities and is used in various diseases. Aim of the study: We investigated the role of M. officinalis extract (MOE) against ischemia-induced arrhythmias and heart injury after five days of reperfusion in an in-vivo rat model of regional heart ischemia. The leaf extract of M. officinalis was standardized thr...

Abstract Melissa officinalis has antioxidant and anti-inflammatory activities and is used in various diseases. Aim of the study: We investigated the role of M. officinalis extract (MOE) against ischemia-induced arrhythmias and heart injury after five days of reperfusion in an in-vivo rat model of regional heart ischemia. The leaf extract of M. officinalis was standardized thr...

Background: According to increased consumption of supplements especially during pregnancy and the teratogenic impact some they on evolution the vital systems of embryos. The purpose of this study to Improve the health of the fetus and prevention of cardiovascular abnormalities as the most common cause of infant mortality. We examined the effects of L-Arginine and L-NAME administration on fetal ...

background melissa officinalis, an herbal drug, is well known and frequently applied in traditional and modern medicine. yet, there is inadequate information regarding its effects on electrical properties of the heart. the present study attempted to elucidate the effects of melissa officinalis aqueous extract on electrocardiogram (ecg) in rat. objectives ecg is an easy, fast and valuable tool t...

background & objectives: cardiovascular effects of herbal medicine were shown in numerous studies. falcaria vulgaris or gazayag has traditionally been used in kermanshah as an herbal medicine and its beneficial effect on peptic ulcer and skin wound has been proved in previous studies. there is some evidence about its cardiac effect. in addition, special chemical substance called butylidenephtha...

Hydrogen sulfide (H₂S) has recently emerged as an important mediator of mammalian cardiovascular homeostasis. In nonmammalian vertebrates, little is known about the cardiac effects of H₂S. This study aimed to evaluate, in the avascular heart of the frog, Rana esculenta, whether and to what extent H₂S affects the cardiac performance, and what is the mechanism of action responsible for the observ...

The density of adenosine receptors in membranes derived from rat hearts is 25 times lower than the density of receptors in rat brain membranes. Consequently, adenosine radioligands which are useful in brain such as /-[HJphenylisopropyladenosine, [H]cydohexyladenosine/ [H]-2-chloroadenosine and f-[I]hydroxyphenylisopropyladenosine are of limited usefulness in heart, due to a high ratio of nonspe...

Intact mitochondria from human, beef, and rat heart, as well as rat brain and rat skeletal and smooth muscle, contain considerable creatine kinase activity; those from rat or rabbit liver, kidney, and testis contain essentially none. In rat heart mitochondria creatine kinase activity is far higher than the activity of adenylate kinase and nucleoside diphosphokinase. The heart mitochondrial crea...