mental research (e.g., human impacts on water quality, efficiency of agricultural water use, and trace gas imFrontiers in any science are generally defined by measurement pacts on global climate change) similarly contain stublimitations, and that is especially true in environmental biophysics. born instrumentation problems. I have made no attempt Among the more persistent issues are surface–atm...

BACKGROUND Considered only in terms of tolerance of, or sensitivity to, desiccation (which is an oversimplification), orthodox seeds are those which tolerate dehydration and are storable in this condition, while highly recalcitrant seeds are damaged by loss of only a small proportion of water and are unstorable for practical purposes. Between these extremes, however, there may be a gradation of...

Knee arthrodesis is an alternative to amputation for treating recalcitrant septic non-union of the proximal tibia with bone loss, soft-tissue compromise, and knee-joint involvement. Nonetheless, arthrodesis is difficult to achieve if bone loss is massive, and the septic environment can result in failed bone fusion. We report on a 77-year-old man with massive bone loss secondary to recalcitrant ...

Sir, Recalcitrant warts remains a major therapeutic challenge for patients as well as for dermatologists, and an effective, painless, atraumatic treatment modality is needed world-wide. Topical immunotherapy has for years been used with some success in the treatment of resistant warts (1). Dinitrochlorobenzene (DNCB) was the ®rst contact sensitizer to be used but diphenylcyclopropenone (DCP) is...