In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

The protein releasing kinetics of Saccharomyces cerevisiae cells were investigated by using the ultrasonication method. The effects of acoustic power, duty cycle % of a sonicator, medium pH and cell concentration on protein release were examined. An attempt was also made to enhance cell disruption further by adding glass beads to the solution. An increase with protein release was observed with ...

AIM The development of a new pellets formulation which is able to modulate the release of metoprolol tartrate, an active pharmaceutical ingredient very soluble in water and therefore very difficult to process. MATERIALS AND METHODS Two types of different viscosity grade hydroxypropyl methylcellulose (Methocel K100; HPMC 15.000) and Eudragit NE30D are used as prolonged drug release agents, thu...

the objective of this study was to formulate and evaluate the drug-polymer interaction of mefenamic acid (ma) using two polymers with different characteristics as ethylcellulose (ec) and/or cellulose acetate phthalate (cap). microspheres were prepared by the modified emulsion solvent evaporation (mese). the effect of drug-polymer interaction was studied for each of microspheres. important param...

the purpose of this study was preparation and evaluation of sustained release matrix type ocular mini-tablets of timolol maleate, as a potential formulation for the treatment of glaucoma. following the initial studies on timolol maleate powder, it was formulated into ocular mini-tablets. the polymers investigated in this study included cellulose derivatives (hec, cmc, ec) and carbopol971p. mann...

To explore the relationship between total cyanide and easily liberatable in tailings its impact on environment, leaching release characteristics of a pond were studied using dynamic experiment, model was established. The results show that concentration is higher than cyanide. With increase time, more sensitive to intensity. first-order kinetic, second-order modified Elovich, double constant, pa...