hypertension crisis is one of the main health problems and its effective treatment is of high importance. for this purpose, fast-disintegrating and sustained release formulations of captopril, as a drug of choice, were prepared using conventional mucoadhesive polymers hydroxypropyl methylcellulose (hpmc), sodium carboxymethyl cellulose (na-cmc), hydroxypropyl cellulose (hpc), carbopol 934 (cp93...

the main objective of present research work is to formulate the clopidogrel fast dissolving tablets. clopidogrel, an antiplatelet drug, belongs to bcs class-ii and used to control heart attack, hypertension by inhibiting platelet activation and aggregation .the fast dissolving tablets of clopidogrel were prepared employing different concentrations of crospovidone and croscarmellose sodium in di...

The study aimed at determining the effect of acid modified porcine mucin powder on the release and permeation of insulin in transdermal patches. Various batches of insulin patches were prepared by solvent casting method using polysorbate 80 as emulsifying agent and acid treated and untreated mucin powders as base. The patches were evaluated for their physical properties, folding endurance, moi...

current study is aimed to compare fluride release in conventional glass ionomer, light-cured glass ionomer and compomers. standard samples from the aforementioned materials were prepared and measured by selective fluride ion electrode in intervals of 24hours, 1,2,3 and 4 weeks in neutral ph of 7 and acidic ph of 4.5. the obtained data represented that fluride ion release decreased in time but t...

solid lipid nanoparticles (slns) have emerged as an alternative colloidal carriers for sustained release of lipophilic drugs with poor absorption and water solubility. this manuscript describes the effect of process variables on the production of solid lipid nanoparticles (slns) from beeswax and carnauba wax and ketoprofen release from these carriers. it was found that by increasing drug conten...

Dry mouth can be caused by medication, CPAP use, radiation treatment and a variety of connective tissue diseases, with the prevalence increasing with age. In most individuals, daytime dryness is easily managed. However, except for a new product tested in this study, there is no product lasting longer than an hour that can be used at night to reduce the perception of oral dryness while sleeping....

in this study, attempts were made to evaluate the effect of various acrylic acid based carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol hcl, from matrix-type tablets invitro. for this purpose, tablets containing 160 mg of propranolol hcl along with various amounts of carbopols 934 (c934), 971 (c971), 974 (c974) and pemulen (pem) were prepared using the wet gr...

till date, most of the drugs have been given in conventional immediate release dosage form. nimorazole is an anticancer drug, used as a hypoxic radiosensitizer in patients undergoing radiotherapy and no formulation has been available in the market till now. hence, for the purpose to develop an immediate release dosage form, a statistical optimization process has been employed to quantify the ef...