Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis (RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines and chemokines in the synovial fluid of patients with early synovitis. Synovial ...

Abstract Background Rheumatoid arthritis (RA) is a common disabling joint disease affecting both males and females. Sexual dysfunction (SD) association with RA. The aim of this work was to study the prevalence predictors sexual in male female patients rheumatoid arthritis. Results mean age 32.1 years 39.7 for males. higher RA than controls, 62.1% versus 41.2% respectively ( P ≤ 0.05). global 63...

Background The 2010 rheumatoid arthritis (RA) classification criteria are intended for research purposes and of the disease not diagnostic purposes. It is however a tool which clinicians commonly use in everyday practice when evaluating patients with arthritis. clearly stated that synovitis should be better explained by another disease. However, some who classified as seronegative RA might stil...

OBJECTIVE The involvement of cytokines and chemokines in the pathogenesis of rheumatoid arthritis (RA) is well studied; however, the genetic bases behind this is not well understood. The aim of this study was to examine whether -572 G/C polymorphism in the IL-6 gene and 2767 A/G polymorphism in the 3'-untranslated region (UTR) of the IL-8 gene are associated with rheumatoid arthritis (RA). ME...

INTRODUCTION Anti-carbamylated protein (anti-CarP) antibodies have been described in rheumatoid arthritis (RA) and arthralgia patients at risk of developing RA. To what extent these autoantibodies are specific for RA is unknown. Therefore, we investigated the diagnostic performance of the presence of anti-CarP antibodies for RA in a setting of early arthritis. METHODS Anti-CarP antibodies wer...

Background: Rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) are systemic autoimmune diseases characterized by synovitis and a wide range of extra articular manifestations. Ocular involvement occurs frequently in both diseases and it may affect all layers. Objectives: To identify different types of ocular involvement in cases of Adult Rheumatoid Arthritis (RA) and Juvenile Rheu...

Class-specific rheumatoid factors (RFs) were measured by enzyme immunoassay in 59 patients with rheumatoid arthritis complicated by systemic amyloidosis (RA+A), 47 patients with rheumatoid arthritis without amyloid (RA), 106 patients with other rheumatic diseases (juvenile rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome), and 55 blood donors. The patients with RA+A were c...

In the last decades, there has been a significant evolution in the knowledge of rheumatoid arthritis (RA) physiopathogeny, leading to changes in disease’s approach and therapeutics. The concept of “early or initial rheumatoid arthritis” was defined by the majority of authors as the initial phase of disease symptoms up to 12 months, period of time in which Distinct pattern of rheumatoid factor s...

BACKGROUND Personal factors (PFs) are internal factors that determine functioning and the individuals' experience of disability. Their coverage by patient-reported outcome measures (PROMs) has not been examined in rheumatoid arthritis (RA) so far. The aims of this study were to identify PFs important in the life stories of people with RA and to determine their coverage by PROMs used in RA. ME...