This paper addresses the topic of online unsupervised speaker segmentation in a complex audio environment as it is present in the Broadcast News databases. A new two stage speaker change detection algorithm is proposed, which combines the Bayesian Information Criterion with an ABLS-SCD statistical framework where adapted Gaussian mixture models are used to achieve higher accuracy. To enhance th...

BACKGROUND Sickle-cell disease (SCD) is the most common inherited genetic disorder in sub-Saharan Africa, and it is associated with early mortality and lifelong morbidity. Early diagnosis is essential for instituting appropriate care and preventive therapy. OBJECTIVE To compare parental knowledge or perception of their offspring's hemoglobin phenotype prior to testing and actual validated lab...

Sickle cell haemoglobin D disease (D-Punjab) is a rare variant of sickle (SCD) reported from central India. Exact incidence pulmonary thrombosis in patients with HbSD unknown. Pulmonary known complication SCD but case pattern. We 34-year-old male patient acute chest syndrome (ACS). CT angiogram revealed near complete right middle lobe segmental and subsegmental branches infarct. Our responded t...

Background: Although several studies have been done on quality of life of patients with Sickle Cell Disease (SCD), there is little research on the correlation of health-related quality of life (HRQoL) with self-efficacy in these patients. We aimed to determine the association between HRQoL and self-efficacy in patients with SCD and to explore the role of self-efficacy and demographic-clinical v...

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim (1 of 9) 1600100 wileyonlinelibrary.com 10–20 d (compared to 120 d in patients without the disease), resulting in a low RBC count and low level of hemoglobin (anemia).[4] Deoxygenation results in HbS polymerization and RBC shape change to the rheologically unfavorable sickle form that can inhibit blood flow and cause organ damage, stroke, infect...

Background: The inherited disorders of haemoglobin are the commonest single gene disorder of the world population. Sickle cell anaemia being the most widespread and numerically the most important haemoglobinopathy in the world today. The major features of sickle cell disease (SCD) in most patients are lifelong anaemia and the consequences of recurrent vaso-occlusion. Many complications of SCD i...

Abstract  Red blood cells (RBCs) from patients with sickle cell disease (SCD) lyse in deoxygenated isosmotic non-electrolyte solutions. Haemolysis has features which suggest that it is linked to activation of the pathway termed Psickle. This pathway is usually described as a non-specific cationic conductance activated by deoxygenation, HbS polymerisation and RBC sickling. The current work addre...

OBJECTIVE To investigate the association between semicircular canal dehiscence (SCD) and Chiari type I malformation (CM-I). DESIGN Retrospective case series. SETTING Military tertiary referral center. PATIENTS Adult patients with SCD. INTERVENTION Review of records of patients diagnosed as having SCD for the radiologic diagnosis of CM-I and presenting symptoms. MAIN OUTCOME MEASURES T...

Chronic inflammation is a poorly understood, but problematic, manisfestation of sickle cell disease (SCD). The potent inflammatory mediator CD40L increases leukocyte proliferation, endothelial adhesiveness and procoagulant activity once it is exposed and released from encrypted sites following platelet activation. Since elevated leukocyte counts, adhesion and coagulation are associated with mor...