Phosphodiesterase 4 (PDE4) has been established as a promising target in asthma andchronic obstructive pulmonary disease. PDE4B subtype selective inhibitors are known toreduce the dose limiting adverse effect associated with non-selective PDE4B inhibitors. Thismakes the development of PDE4B subtype selective inhibitors a desirable research goal. Toachieve this goal, ligand based pharmacophore m...

in this work, we developed a simple and selective method for separation and spectrophotometric determination of trace amounts of cetylpyridinium chloride (cpc) in pharmaceutical products using cloud point extraction (cpe) technique. the method is based on cloud point extraction of the cpc in alkali conditions using of nonionic surfactant triton x-114. under selected conditions, the calibration ...

Hollow mesoporous silica particles (HMSPs) have recently drawn much attention as nanocatalysts, owing to their benefits and potential for greener chemical processes. Here, improved synthesis of HMSPs exhibiting a shell with 3-D pore structure is proposed overcome previous synthetic issues, such reproducibility, particle size distribution, precise tailoring size/shell thickness, low yield, etc. ...

This paper presents a general approach to sequential blind extraction of instantaneously mixed sources for several major ill-conditioned cases as well as the regular case of full column rank mixing matrices. Four ill-conditioned cases are considered: The mixing matrix is square but singular; the number of sensors is less than that of sources; the number of sensors is larger than that of sources...

Sequential ultrasound-microwave associated extraction (SUMAE) is a combination of ultrasound waves and microwaves energies in which ultrasonic extraction is used as a pretreatment. It was performed to extract essential oil from Zataria multiflora. The extraction conditions were optimized by response surface methodology (RSM) and Central Composite Design (CCD). The antioxidant and antibacterial ...

Sixteen USEPA priority polycyclic aromatic hydrocarbons (PAHs) extracted by Soxhlet extraction (S-PAHs) with dichloromethane and routine accelerated solvent extraction (A-PAHs) with 1:1 toluene/methanol, respectively, were investigated in 24 soil samples from two cities in the center of the Pearl River Delta, South China. Polycyclic aromatic hydrocarbons, methylphenanthrene and perylene, in two...

Shape memory (SM) materials have been widely investigated for several years. Most polymers present SM behaviour based on their thermo-mechanical properties. However, they are usually stimulated by an external heating source, hindering industrial application. The addition of carbon nanotubes (CNT) allows turning conventional into electro-active actuators. In this regard, the resistive Joule effe...